Abstract: Lung cancer is one of the most diagnosed cancers among men and women. Actually,
lung cancer accounts for 13% of the total cases with a 5-year global survival
rate in patients. Although Early detection increases survival rate from 38% to 67%, accurate diagnosis remains a challenge. Pathological confirmation requires extracting a sample of the lesion tissue for its biopsy. The preferred procedure for tissue biopsy is called bronchoscopy. A bronchoscopy is an endoscopic technique for the internal exploration of airways which facilitates the performance of minimal invasive interventions with low risk for the patient. Recent advances in bronchoscopic devices have increased their use for minimal invasive diagnostic and intervention procedures, like lung cancer biopsy sampling. Despite the improvement in bronchoscopic device quality, there is a lack of intelligent computational systems for supporting in-vivo clinical decision during examinations. Existing technologies fail to accurately reach the lesion due to several aspects at intervention off-line planning and poor intra-operative guidance at exploration time. Existing guiding systems radiate patients and clinical staff,might be expensive and achieve a suboptimlal 70% of yield boost. Diagnostic yield could be improved reducing radiation and costs by developing intra-operative support systems able to guide the bronchoscopist to the lesion during the intervention. The goal of this PhD thesis is to develop an image-based navigation systemfor intra-operative guidance of bronchoscopists to a target lesion across a path previously planned on a CT-scan. We propose a 3D navigation system which uses the anatomy of video bronchoscopy frames to locate the bronchoscope within the airways. Once the bronchoscope is located, our navigation system is able to indicate the bifurcation which needs to be followed to reach the lesion. In order to facilitate an off-line validation
as realistic as possible, we also present a method for augmenting simulated virtual bronchoscopies with the appearance of intra-operative videos. Experiments performed on augmented and intra-operative videos, prove that our algorithm can be speeded up for an on-line implementation in the operating room.

Abstract: As any iterative technique, it is a necessary condition a stop criterion for terminating Evolutionary Algorithms (EA). In the case of optimization methods, the algorithm should stop at the time it has reached a steady state so it can not improve results anymore. Assessing the reliability of termination conditions for EAs is of prime importance. A wrong or weak stop criterion can negatively aect both the computational eort and the nal result.
In this Thesis, we introduce a statistical framework for assessing whether a termination condition is able to stop EA at its steady state. In one hand a numeric approximation to steady states to detect the point in which EA population has lost its diversity has been presented for EA termination. This approximation has been applied to dierent EA paradigms based on diversity and a selection of functions covering the properties most relevant for EA convergence. Experiments show that our condition works regardless of the search space dimension and function landscape and Dierential Evolution (DE) arises as the best paradigm. On the other hand, we use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in xspace.
Our theoretical framework is analyzed across several benchmark test functions
and two standard termination criteria based on function improvement in f-space and EA population x-space distribution for the DE paradigm. Results validate our statistical framework as a powerful tool for determining the capability of a measure for terminating EA and select the x-space distribution as the best-suited for accurately stopping DE in real-world applications.

Abstract: This thesis addresses the problem of automatic scene text understanding in unconstrained conditions. In particular, we tackle the tasks of multi-language and arbitrary-oriented text detection, tracking, and script identification in natural scenes.
For this we have developed a set of generic methods that build on top of the basic observation that text has always certain key visual and structural characteristics that are independent of the language or script in which it is written. Text instances in any
language or script are always formed as groups of similar atomic parts, being them either individual characters, small stroke parts, or even whole words in the case of cursive text. This holistic (sumof-parts) and recursive perspective has lead us to explore different variants of the “segmentation and grouping” paradigm of computer vision.
Scene text detection methodologies are usually based in classification of individual regions or patches, using a priory knowledge for a given script or language. Human perception of text, on the other hand, is based on perceptual organization through which
text emerges as a perceptually significant group of atomic objects.
In this thesis, we argue that the text detection problem must be posed as the detection of meaningful groups of regions. We address the problem of text detection in natural scenes from a hierarchical perspective, making explicit use of the recursive nature of text, aiming directly to the detection of region groupings corresponding to text within a hierarchy produced by an agglomerative similarity clustering process over individual regions. We propose an optimal way to construct such an hierarchy introducing a feature space designed to produce text group hypothese with high recall and a novel stopping rule combining a discriminative classifier and a probabilistic measure of group meaningfulness based in perceptual organization. Within this generic framework, we design a text-specific object proposals algorithm that, contrary to existing generic object proposals methods, aims directly to the detection of text regions groupings. For this, we abandon the rigid definition of “what is text” of traditional specialized text detectors, and move towards more fuzzy perspective of grouping-based object proposals methods.
Then, we present a hybrid algorithm for detection and tracking of scene text where the notion of region groupings plays also a central role. By leveraging the structural arrangement of text group components between consecutive frames we can improve
the overall tracking performance of the system.
Finally, since our generic detection framework is inherently designed for multi-language environments, we focus on the problem of script identification in order to build a multi-language end-toend reading system. Facing this problem with state of the art CNN classifiers is not straightforward, as they fail to address a key
characteristic of scene text instances: their extremely variable aspect ratio. Instead of resizing input images to a fixed size as in the typical use of holistic CNN classifiers, we propose a patch-based classification framework in order to preserve discriminative parts of the image that are characteristic of its class. We describe a novel method based on the use of ensembles of conjoined networks to jointly learn discriminative stroke-parts representations and their relative importance in a patch-based classification scheme.

Abstract: Searching for text objects in real scene images is an open problem and a very active computer vision research area. A large number of methods have been proposed tackling the text search as extension of the ones from the document analysis field or inspired by general purpose object detection methods. However the general problem of object search in real scene images remains an extremely challenging problem due to the huge variability in object appearance. This thesis builds on top of the most recent findings in the visual attention literature presenting a novel computational model of eye guidance aiming to better describe text object search in real scene images.
First are presented the relevant state-of-the-art results from the visual attention literature regarding eye movements and visual search. Relevant models of attention are discussed and integrated with recent observations on the role of top-down constraints and the emerging need for a layered model of attention in which saliency is not the only factor guiding attention. Visual attention is then explained by the interaction of several modulating factors, such as objects, value, plans and saliency. Then we introduce our probabilistic formulation of attention deployment in real scene. The model is based on the rationale that oculomotor control depends on two interacting but distinct processes: an attentional process that assigns value to the sources of information and motor process that flexibly links information with action.
In such framework, the choice of where to look next is task-dependent and oriented to classes of objects embedded within pictures of complex scenes. The dependence on task is taken into account by exploiting the value and the reward of gazing at certain image patches or proto-objects that provide a sparse representation of the scene objects.
In the experimental section the model is tested in laboratory condition, comparing model simulations with data from eye tracking experiments. The comparison is qualitative in terms of observable scan paths and quantitative in terms of statistical similarity of gaze shift amplitude. Experiments are performed using eye tracking data from both a publicly available dataset of face and text and from newly performed eye-tracking experiments on a dataset of street view pictures containing text. The last part of this thesis is dedicated to study the extent to which the proposed model can account for human eye movements in a low constrained setting. We used a mobile eye tracking device and an ad-hoc developed methodology to compare model simulated eye data with the human eye data from mobile eye tracking recordings. Such setting allow to test the model in an incomplete visual information condition, reproducing a close to real-life search task.

Abstract: Until recently, most computer vision models remained illiterate, largely ignoring the semantically rich and explicit information contained in scene text. Recent progress in scene text detection and recognition has recently allowed exploring its role in a diverse set of open computer vision problems, e.g. image classification, image-text retrieval, image captioning, and visual question answering to name a few. The explicit semantics of scene text closely requires specific modeling similar to language. However, scene text is a particular signal that has to be interpreted according to a comprehensive perspective that encapsulates all the visual cues in an image. Incorporating this information is a straightforward task for humans, but if we are unfamiliar with a language or scripture, achieving a complete world understanding is impossible (e.a. visiting a foreign country with a different alphabet). Despite the importance of scene text, modeling it requires considering the several ways in which scene text interacts with an image, processing and fusing an additional modality. In this thesis, we mainly focus
on two tasks, scene text-based fine-grained image classification, and cross-modal retrieval. In both studied tasks we identify existing limitations in current approaches and propose plausible solutions. Concretely, in each chapter: i) We define a compact way to embed scene text that generalizes to unseen words at training time while performing in real-time. ii) We incorporate the previously learned scene text embedding to create an image-level descriptor that overcomes optical character recognition (OCR) errors which is well-suited to the fine-grained image classification task. iii) We design a region-level reasoning network that learns the interaction through semantics among salient visual regions and scene text instances. iv) We employ scene text information in image-text matching and introduce the Scene Text Aware Cross-Modal retrieval StacMR task. We gather a dataset that incorporates scene text and design a model suited for the newly studied modality. v) We identify the drawbacks of current retrieval metrics in cross-modal retrieval. An image captioning metric is proposed as a way of better evaluating semantics in retrieved results. Ample experimentation shows that incorporating such semantics into a model yields better semantic results while
requiring significantly less data to converge.

Abstract: Pattern recognition is the task that aims at distinguishing objects among different classes. When such a task wants to be solved in an automatic way a crucial step is how to formally represent such patterns to the computer. Based on the different representational formalisms, we may distinguish between statistical and structural pattern recognition. The former describes objects as a set of measurements arranged in the form of what is called a feature vector. The latter assumes that relations between parts of the underlying objects need to be explicitly represented and thus it uses relational structures such as graphs for encoding their inherent information. Vector spaces are a very flexible mathematical structure that has allowed to come up with several efficient ways for the analysis of patterns under the form of feature vectors. Nevertheless, such a representation cannot explicitly cope with binary relations between parts of the objects and it is restricted to measure the exact same number of features for each pattern under study regardless of their complexity. Graph-based representations present the contrary situation. They can easily adapt to the inherent complexity of the patterns but introduce a problem of high computational complexity, hindering the design of efficient tools to process and analyse patterns.
Solving this paradox is the main goal of this thesis. The ideal situation for solving pattern recognition problems would be to represent the patterns using relational structures such as graphs, and to be able to use the wealthy repository of data processing tools from the statistical pattern recognition domain. An elegant solution to this problem is to transform the graph domain into a vector domain where any processing algorithm can be applied. In other words, by mapping each graph to a point in a vector space we automatically get access to the rich set of algorithms from the statistical domain to be applied in the graph domain. Such methodology is called graph embedding.
In this thesis we propose to associate feature vectors to graphs in a simple and very efficient way by just putting attention on the labelling information that graphs store. In particular, we count frequencies of node labels and of edges between labels. Although their locality, these features are able to robustly represent structurally global properties of graphs, when considered together in the form of a vector. We initially deal with the case of discrete attributed graphs, where features are easy to compute. The continuous case is tackled as a natural generalization of the discrete one, where rather than counting node and edge labelling instances, we count statistics of some representatives of them. We encounter how the proposed vectorial representations of graphs suffer from high dimensionality and correlation among components and we face these problems by feature selection algorithms. We also explore how the diversity of different embedding representations can be exploited in order to boost the performance of base classifiers in a multiple classifier systems framework. An extensive experimental evaluation finally shows how the methodology we propose can be efficiently computed and compete with other graph matching and embedding methodologies.

Abstract: Visual Question Answering (VQA) is the task where given an image and a natural language question, the objective is to generate a natural language answer. At the intersection between computer vision and natural language processing, this task can be seen as a measure of image understanding capabilities, as it requires to reason about objects, actions, colors, positions, the relations between the different elements as well as commonsense reasoning, world knowledge, arithmetic skills and natural language understanding. However, even though the text present in the images conveys important semantically rich information that is explicit and not available in any other form, most VQA methods remained illiterate, largely
ignoring the text despite its potential significance. In this thesis, we set out on a journey to bring reading capabilities to computer vision models applied to the VQA task, creating new datasets and methods that can read, reason and integrate the text with other visual cues in natural scene images and documents.
In Chapter 3, we address the combination of scene text with visual information to fully understand all the nuances of natural scene images. To achieve this objective, we define a new sub-task of VQA that requires reading the text in the image, and highlight the limitations of the current methods. In addition, we propose a new architecture that integrates both modalities and jointly reasons about textual and visual features. In Chapter 5, we shift the domain of VQA with reading capabilities and apply it on scanned industry document images, providing a high-level end-purpose perspective to Document Understanding, which has been
primarily focused on digitizing the document’s contents and extracting key values without considering the ultimate purpose of the extracted information. For this, we create a dataset which requires methods to reason about the unique and challenging elements of documents, such as text, images, tables, graphs and complex layouts, to provide accurate answers in natural language. However, we observed that explicit visual features provide a slight contribution in the overall performance, since the main information is usually conveyed within the text and its position. In consequence, in Chapter 6, we propose VQA on infographic images, seeking for document images with more visually rich elements that require to fully exploit visual information in order to answer the questions. We show the performance gap of
different methods when used over industry scanned and infographic images, and propose a new method that integrates the visual features in early stages, which allows the transformer architecture to exploit the visual features during the self-attention operation. Instead, in Chapter 7, we apply VQA on a big collection of single-page documents, where the methods must find which documents are relevant to answer the question, and provide the answer itself. Finally, in Chapter 8, mimicking real-world application problems where systems must process documents with multiple pages, we address the multipage document visual question answering task. We demonstrate the limitations of existing methods, including models specifically designed to process long sequences. To overcome these limitations, we propose
a hierarchical architecture that can process long documents, answer questions, and provide the index of the page where the information to answer the question is located as an explainability measure.