Abstract: The framework of this thesis is to study in detail different techniques and tools for medical image registration in order to ease the daily life of clinical experts in cardiology. The first aim of this thesis is providing computer tools for
fusing IVUS and angiogram data is of high clinical interest to help the physicians locate in IVUS data and decide which lesion is observed, how long it is, how far from a bifurcation or another lesions stays, etc. This thesis proves and
validates that we can segment the catheter path in angiographies using geodesic snakes (based on fast marching algorithm), a three-dimensional reconstruction of the catheter inspired in stereo vision and a new technique to fuse IVUS
and angiograms that establishes exact correspondences between them. We have developed a new workstation called iFusion that has four strong advantages: registration of IVUS and angiographic images with sub-pixel precision, it works on- and off-line, it is independent on the X-ray system and there is no need of daily calibration. The second aim of the thesis is devoted to developing a computer-aided analysis of IVUS for image-guided intervention. We have designed, implemented
and validated a robust algorithm for stent extraction and reconstruction from IVUS videos. We consider a very special and recent kind of stents, bioabsorbable stents that represent a great clinical challenge due to their property to be
absorbed by time and thus avoiding the “danger” of neostenosis as one of the main problems of metallic stents. We present a new and very promising algorithm based on an optimized cascade of multiple classifiers to automatically detect individual stent struts of a very novel bioabsorbable drug eluting coronary stent. This problem represents a very challenging target given the variability in contrast, shape and grey levels of the regions to be detected, what is
denoted by the high variability between the specialists (inter-observer variability of 0.14~$\pm$0.12). The obtained results of the automatic strut detection are within the inter-observer variability.

Abstract: Image segmentations aims to partition an image into a set of non-overlapped regions, called segments. Despite the simplicity of the definition, image segmentation raises as a very complex problem in all its stages. The definition of segment is still unclear. When asking to a human to perform a segmentation, this person segments at different levels of abstraction. Some segments might be a single, well-defined texture whereas some others correspond with an object in the scene which might including multiple textures and colors. For this reason, segmentation is divided in bottom-up segmentation and top-down segmentation. Bottom up-segmentation is problem independent, that is, focused on general properties of the images such as textures or illumination. Top-down segmentation is a problem-dependent approach which looks for specific entities in the scene, such as known objects. This work is focused on bottom-up segmentation. Beginning from the analysis of the lacks of current methods, we propose an approach called RAD. Our approach overcomes the main shortcomings of those methods which use the physics of the light to perform the segmentation. RAD is a topological approach which describes a single-material reflectance. Afterwards, we cope with one of the main problems in image segmentation: non supervised adaptability to image content. To yield a non-supervised method, we use a model of saliency yet presented in this thesis. It computes the saliency of the chromatic transitions of an image by means of a statistical analysis of the images derivatives. This method of saliency is used to build our final approach of segmentation: spRAD. This method is a non-supervised segmentation approach. Our saliency approach has been validated with a psychophysical experiment as well as computationally, overcoming a state-of-the-art saliency method. spRAD also outperforms state-of-the-art segmentation techniques as results obtained with a widely-used segmentation dataset show

Abstract: Image values are the result of a combination of visual information coming from multiple sources. Recovering information from the multiple factors thatproduced an image seems a hard and ill-posed problem. However, it is important to observe that humans develop the ability to interpret images and recognize and isolate specific physical properties of the scene.
Images describing a single physical characteristic of an scene are called intrinsic images. These images would benefit most computer vision tasks which are often affected by the multiple complex effects that are usually found in natural images (e.g. cast shadows, specularities, interreflections...).
In this thesis we analyze the problem of intrinsic image estimation from different perspectives, including the theoretical formulation of the problem, the visual cues that can be used to estimate the intrinsic components and the evaluation mechanisms of the problem.

Abstract: Nowadays, digital images are used in many areas in everyday life, but they tend to be big. This increases amount of information leads us to the problem of image data storage. For example, it is common to have a representation a color pixel as a 24-bit number, where the channels red, green, and blue employ 8 bits each. In consequence, this kind of color pixel can specify one of 224 ¼ 16:78 million colors. Therefore, an image at a resolution of 512 £ 512 that allocates 24 bits per pixel, occupies 786,432 bytes. That is why image compression is important. An important feature of image compression is that it can be lossy or lossless. A compressed image is acceptable provided these losses of image information are not perceived by the eye. It is possible to assume that a portion of this information is redundant. Lossless Image Compression is defined as to mathematically decode the same image which was encoded. In Lossy Image Compression needs to identify two features inside the image: the redundancy and the irrelevancy of information. Thus, lossy compression modifies the image data in such a way when they are encoded and decoded, the recovered image is similar enough to the original one. How similar is the recovered image in comparison to the original image is defined prior to the compression process, and it depends on the implementation to be performed. In lossy compression, current image compression schemes remove information considered irrelevant by using mathematical criteria. One of the problems of these schemes is that although the numerical quality of the compressed image is low, it shows a high visual image quality, e.g. it does not show a lot of visible artifacts. It is because these mathematical criteria, used to remove information, do not take into account if the viewed information is perceived by the Human Visual System. Therefore, the aim of an image compression scheme designed to obtain images that do not show artifacts although their numerical quality can be low, is to eliminate the information that is not visible by the Human Visual System. Hence, this Ph.D. thesis proposes to exploit the visual redundancy existing in an image by reducing those features that can be unperceivable for the Human Visual System. First, we define an image quality assessment, which is highly correlated with the psychophysical experiments performed by human observers. The proposed CwPSNR metrics weights the well-known PSNR by using a particular perceptual low level model of the Human Visual System, e.g. the Chromatic Induction Wavelet Model (CIWaM). Second, we propose an image compression algorithm (called Hi-SET), which exploits the high correlation and self-similarity of pixels in a given area or neighborhood by means of a fractal function. Hi-SET possesses the main features that modern image compressors have, that is, it is an embedded coder, which allows a progressive transmission. Third, we propose a perceptual quantizer (½SQ), which is a modification of the uniform scalar quantizer. The ½SQ is applied to a pixel set in a certain Wavelet sub-band, that is, a global quantization. Unlike this, the proposed modification allows to perform a local pixel-by-pixel forward and inverse quantization, introducing into this process a perceptual distortion which depends on the surround spatial information of the pixel. Combining ½SQ method with the Hi-SET image compressor, we define a perceptual image compressor, called ©SET. Finally, a coding method for Region of Interest areas is presented, ½GBbBShift, which perceptually weights pixels into these areas and maintains only the more important perceivable features in the rest of the image. Results presented in this report show that CwPSNR is the best-ranked image quality method when it is applied to the most common image compression distortions such as JPEG and JPEG2000. CwPSNR shows the best correlation with the judgement of human observers, which is based on the results of psychophysical experiments obtained for relevant image quality databases such as TID2008, LIVE, CSIQ and IVC. Furthermore, Hi-SET coder obtains better results both for compression ratios and perceptual image quality than the JPEG2000 coder and other coders that use a Hilbert Fractal for image compression. Hence, when the proposed perceptual quantization is introduced to Hi-SET coder, our compressor improves its numerical and perceptual e±ciency. When ½GBbBShift method applied to Hi-SET is compared against MaxShift method applied to the JPEG2000 standard and Hi-SET, the images coded by our ROI method get the best results when the overall image quality is estimated. Both the proposed perceptual quantization and the ½GBbBShift method are generalized algorithms that can be applied to other Wavelet based image compression algorithms such as JPEG2000, SPIHT or SPECK.

Abstract: Humansmove their eyes in order to learn visual representations of the world. These eye movements depend on distinct factors, either by the scene that we perceive or by our own decisions. To select what is relevant to attend is part of our survival mechanisms and the way we build reality, as we constantly react both consciously and unconsciously to all the stimuli that is projected into our eyes. In this thesis we try to explain (1) how we move our eyes, (2) how to build machines that understand visual information and deploy eyemovements, and (3) how to make these machines understand tasks in order to decide for eye movements.
(1) We provided the analysis of eye movement behavior elicited by low-level feature distinctiveness with a dataset of 230 synthetically-generated image patterns. A total of 15 types of stimuli has been generated (e.g. orientation, brightness, color, size, etc.), with 7 feature contrasts for each feature category. Eye-tracking data was collected from 34 participants during the viewing of the dataset, using Free-Viewing and Visual Search task instructions. Results showed that saliency is predominantly and distinctively influenced by: 1. feature type, 2. feature contrast, 3. Temporality of fixations, 4. task difficulty and 5. center bias. From such dataset (SID4VAM), we have computed a benchmark of saliency models by testing performance using psychophysical patterns. Model performance has been evaluated considering model inspiration and consistency with human psychophysics. Our study reveals that state-of-the-art Deep Learning saliency models do not performwell with synthetic pattern images, instead, modelswith Spectral/Fourier inspiration outperform others in saliency metrics and are more consistent with human psychophysical experimentation.
(2) Computations in the primary visual cortex (area V1 or striate cortex) have long been hypothesized to be responsible, among several visual processing mechanisms, of bottom-up visual attention (also named saliency). In order to validate this hypothesis, images from eye tracking datasets have been processed with a biologically plausible model of V1 (named Neurodynamic SaliencyWaveletModel or NSWAM). Following Li’s neurodynamic model, we define V1’s lateral connections with a network of firing rate neurons, sensitive to visual features such as brightness, color, orientation and scale. Early subcortical processes (i.e. retinal and thalamic) are functionally simulated. The resulting saliency maps are generated from the model output, representing the neuronal activity of V1 projections towards brain areas involved in eye movement control. We want to pinpoint that our unified computational architecture is able to reproduce several visual processes (i.e. brightness, chromatic induction and visual discomfort) without applying any type of training or optimization and keeping the same parametrization. The model has been extended (NSWAM-CM) with an implementation of the cortical magnification function to define the retinotopical projections towards V1, processing neuronal activity for each distinct view during scene observation. Novel computational definitions of top-down inhibition (in terms of inhibition of return and selection mechanisms), are also proposed to predict attention in Free-Viewing and Visual Search conditions. Results show that our model outperforms other biologically-inpired models of saliency prediction as well as to predict visual saccade sequences, specifically for nature and synthetic images. We also show how temporal and spatial characteristics of inhibition of return can improve prediction of saccades, as well as how distinct search strategies (in terms of feature-selective or category-specific inhibition) predict attention at distinct image contexts.
(3) Although previous scanpath models have been able to efficiently predict saccades during Free-Viewing, it is well known that stimulus and task instructions can strongly affect eye movement patterns. In particular, task priming has been shown to be crucial to the deployment of eye movements, involving interactions between brain areas related to goal-directed behavior, working and long-termmemory in combination with stimulus-driven eyemovement neuronal correlates. In our latest study we proposed an extension of the Selective Tuning Attentive Reference Fixation ControllerModel based on task demands (STAR-FCT), describing novel computational definitions of Long-TermMemory, Visual Task Executive and Task Working Memory. With these modules we are able to use textual instructions in order to guide the model to attend to specific categories of objects and/or places in the scene. We have designed our memorymodel by processing a visual hierarchy of low- and high-level features. The relationship between the executive task instructions and the memory representations has been specified using a tree of semantic similarities between the learned features and the object category labels. Results reveal that by using this model, the resulting object localizationmaps and predicted saccades have a higher probability to fall inside the salient regions depending on the distinct task instructions compared to saliency.