Gerard Lacey, & Fernando Vilariño. (2011). Endoscopy system with motion sensors.
Abstract: An endoscopy system (1) comprises an endoscope (2) with a camera (3) at its tip. The endoscope extends through an endoscope guide (4) for guiding movement of the endoscope and for measurement of its movement as it enters the body. The guide (4) comprises a generally conical body (5) having a through passage (105) through which the endoscope (2) extends. A motion sensor comprises an optical transmitter (7) and a detector (8) mounted alongside the passage (105) to measure the insertion-withdrawal linear motion and also rotation of the endoscope by the endoscopist's hand. The system (1) also comprises a flexure controller (10) having wheels operated by the endoscopist. The camera (3), the motion sensor (7/8), and the flexure controller (10) are all connected to a processor (11) which feeds a display.
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Petia Radeva, Jordi Vitria, Fernando Vilariño, Panagiota Spyridonos, Fernando Azpiroz, Juan Malagelada, et al. (2009). Cascade analysis for intestinal contraction detection. US Patent Office.
Abstract: A method and system cascade analysisi for intestinal contraction detection is provided by extracting from image frames captured in-vivo. The method and system also relate to the detection of turbid liquids in intestinal tracts, to automatic detection of video image frames taken in the gastrointestinal tract including a field of view obstructed by turbid media, and more particulary, to extraction of image data obstructed by turbid media.
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Panagiota Spyridonos, Fernando Vilariño, Jordi Vitria, Petia Radeva, Fernando Azpiroz, & Juan Malagelada. (2011). Device, system and method for automatic detection of contractile activity in an image frame.
Abstract: A device, system and method for automatic detection of contractile activity of a body lumen in an image frame is provided, wherein image frames during contractile activity are captured and/or image frames including contractile activity are automatically detected, such as through pattern recognition and/or feature extraction to trace image frames including contractions, e.g., with wrinkle patterns. A manual procedure of annotation of contractions, e.g. tonic contractions in capsule endoscopy, may consist of the visualization of the whole video by a specialist, and the labeling of the contraction frames. Embodiments of the present invention may be suitable for implementation in an in vivo imaging system.
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Michal Drozdzal, Petia Radeva, Santiago Segui, Laura Igual, Carolina Malagelada, Fernando Azpiroz, et al. (2012). System and Method for Improving a Discriminative Model.
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Michal Drozdzal, Santiago Segui, Petia Radeva, Jordi Vitria, & Laura Igual. (2011). System and Method for Displaying Motility Events in an in Vivo Image Stream.
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Eric Amiel. (2005). Visualisation de vaisseaux sanguins (Enric Marti, Ed.). Bachelor's thesis, Université Paul Sabatier Toulouse III, Toulouse.
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Jorge Bernal, F. Javier Sanchez, & Fernando Vilariño. (2011). A Region Segmentation Method for Colonoscopy Images Using a Model of Polyp Appearance. In Mario João and Hernández J. and S. Vitrià (Ed.), 5th Iberian Conference on Pattern Recognition and Image Analysis (Vol. 6669, pp. 134–143 ). LNCS.
Abstract: This work aims at the segmentation of colonoscopy images into a minimum number of informative regions. Our method performs in a way such, if a polyp is present in the image, it will be exclusively and totally contained in a single region. This result can be used in later stages to classify regions as polyp-containing candidates. The output of the algorithm also defines which regions can be considered as non-informative. The algorithm starts with a high number of initial regions and merges them taking into account the model of polyp appearance obtained from available data. The results show that our segmentations of polyp regions are more accurate than state-of-the-art methods.
Keywords: Colonoscopy, Polyp Detection, Region Merging, Region Segmentation.
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Ernest Valveny, & Enric Marti. (2000). Deformable Template Matching within a Bayesian Framework for Hand-Written Graphic Symbol Recognition. Graphics Recognition Recent Advances, 1941, 193–208.
Abstract: We describe a method for hand-drawn symbol recognition based on deformable template matching able to handle uncertainty and imprecision inherent to hand-drawing. Symbols are represented as a set of straight lines and their deformations as geometric transformations of these lines. Matching, however, is done over the original binary image to avoid loss of information during line detection. It is defined as an energy minimization problem, using a Bayesian framework which allows to combine fidelity to ideal shape of the symbol and flexibility to modify the symbol in order to get the best fit to the binary input image. Prior to matching, we find the best global transformation of the symbol to start the recognition process, based on the distance between symbol lines and image lines. We have applied this method to the recognition of dimensions and symbols in architectural floor plans and we show its flexibility to recognize distorted symbols.
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Esmitt Ramirez, Carles Sanchez, Agnes Borras, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2018). BronchoX: bronchoscopy exploration software for biopsy intervention planning. HTL - Healthcare Technology Letters, 177–182.
Abstract: Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.
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David Roche, Debora Gil, & Jesus Giraldo. (2012). Assessing agonist efficacy in an uncertain Em world. In A. Christopoulus and M. Bouvier (Ed.), 40th Keystone Symposia on mollecular and celular biology (79). Keystone Symposia.
Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
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Mariano Vazquez, Ruth Aris, Guillaume Hozeaux, R.Aubry, P.Villar, Jaume Garcia, et al. (2011). A massively parallel computational electrophysiology model of the heart. IJNMBE - International Journal for Numerical Methods in Biomedical Engineering, 27, 1911–1929.
Abstract: This paper presents a patient-sensitive simulation strategy capable of using the most efficient way the high-performance computational resources. The proposed strategy directly involves three different players: Computational Mechanics Scientists (CMS), Image Processing Scientists and Cardiologists, each one mastering its own expertise area within the project. This paper describes the general integrative scheme but focusing on the CMS side presents a massively parallel implementation of computational electrophysiology applied to cardiac tissue simulation. The paper covers different angles of the computational problem: equations, numerical issues, the algorithm and parallel implementation. The proposed methodology is illustrated with numerical simulations testing all the different possibilities, ranging from small domains up to very large ones. A key issue is the almost ideal scalability not only for large and complex problems but also for medium-size meshes. The explicit formulation is particularly well suited for solving this highly transient problems, with very short time-scale.
Keywords: computational electrophysiology; parallelization; finite element methods
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Jaume Garcia, Albert Andaluz, Debora Gil, & Francesc Carreras. (2010). Decoupled External Forces in a Predictor-Corrector Segmentation Scheme for LV Contours in Tagged MR Images. In 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 4805–4808).
Abstract: Computation of functional regional scores requires proper identification of LV contours. On one hand, manual segmentation is robust, but it is time consuming and requires high expertise. On the other hand, the tag pattern in TMR sequences is a problem for automatic segmentation of LV boundaries. We propose a segmentation method based on a predictorcorrector (Active Contours – Shape Models) scheme. Special stress is put in the definition of the AC external forces. First, we introduce a semantic description of the LV that discriminates myocardial tissue by using texture and motion descriptors. Second, in order to ensure convergence regardless of the initial contour, the external energy is decoupled according to the orientation of the edges in the image potential. We have validated the model in terms of error in segmented contours and accuracy of regional clinical scores.
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Fernando Vilariño, Panagiota Spyridonos, Fosca De Iorio, Jordi Vitria, Fernando Azpiroz, & Petia Radeva. (2010). Intestinal Motility Assessment With Video Capsule Endoscopy: Automatic Annotation of Phasic Intestinal Contractions. TMI - IEEE Transactions on Medical Imaging, 29(2), 246–259.
Abstract: Intestinal motility assessment with video capsule endoscopy arises as a novel and challenging clinical fieldwork. This technique is based on the analysis of the patterns of intestinal contractions shown in a video provided by an ingestible capsule with a wireless micro-camera. The manual labeling of all the motility events requires large amount of time for offline screening in search of findings with low prevalence, which turns this procedure currently unpractical. In this paper, we propose a machine learning system to automatically detect the phasic intestinal contractions in video capsule endoscopy, driving a useful but not feasible clinical routine into a feasible clinical procedure. Our proposal is based on a sequential design which involves the analysis of textural, color, and blob features together with SVM classifiers. Our approach tackles the reduction of the imbalance rate of data and allows the inclusion of domain knowledge as new stages in the cascade. We present a detailed analysis, both in a quantitative and a qualitative way, by providing several measures of performance and the assessment study of interobserver variability. Our system performs at 70% of sensitivity for individual detection, whilst obtaining equivalent patterns to those of the experts for density of contractions.
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Albert Andaluz, Francesc Carreras, Debora Gil, & Jaume Garcia. (2010). Una aplicació amigable pel càlcul de indicadors clínics del ventricle esquerre. Barcelona: Biocat.
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Jorge Bernal. (2009). Use of Projection and Back-projection Methods in Bidimensional Computed Tomography Image Reconstruction (Vol. 141). Master's thesis, , Barcelona, Spain.
Abstract: One of the biggest drawbacks related to the use of CT scanners is the cost (in memory and in time) associated. In this project many methods to simulate their functioning, but in a more feasible way (taking an industrial point of view), will be studied.
The main group of techniques that are being used are the one entitled as ’back-projection’. The concept behind is to simulate the X ray emission in CT scans by lines that cross with the image we want to reconstruct.
In the first part of this document euclidean geometry is used to face the tasks of projec- tion and back-projection. After analysing the results achieved it has been proved that this approach does not lead to a fully perfect reconstruction (and also has some other problems related to running time and memory cost). Because of this in the second part of the document ’Filtered Back-projection’ method is introduced in order to improve the results.
Filtered Back-projection methods rely on mathematical transforms (Fourier, Radon) in order to provide more accurate results that can be obtained in much less time. The main cause of this better results is the use of a filtering process before the back-projection in order to avoid high frequency-caused errors.
As a result of this project two different implementations (one for each approach) had been implemented in order to compare their performance.
Keywords: Projection, Back-projection, CT scan, Euclidean geometry, Radon transform
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