Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.

Abstract: In the recent years commercial eye-tracking hardware has become more common, with the introduction of new models from several brands that have better performance and easier setup procedures. A cause and at the same time a result of this phenomenon is the popularity of eye-tracking research directed at marketing, accessibility and usability, among others.
One problem with these hardware components is scalability, because both the price and the necessary expertise to operate them makes it practically impossible in the large scale. In this work, we analyze the feasibility of a software eye-tracking system based on a single, ordinary webcam. Our aim is to discover the limits of such a system and to see whether it provides acceptable performances.
The significance of this setup is that it is the most common setup found in consumer environments, off-the-shelf electronic devices such as laptops, mobile phones and tablet computers. As no special equipment such as infrared lights, mirrors or zoom lenses are used; setting up and calibrating the system is easier compared to other approaches using these components.
Our work is based on the open source application Opengazer, which provides a good starting point for our contributions. We propose several improvements in order to push the system's performance further and make it feasible as a robust, real-time device. Then we carry out an elaborate experiment involving 18 human subjects and 4 different system setups. Finally, we give an analysis of the results and discuss the effects of setup changes, subject differences and modifications in the software.

Abstract: This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission.

Abstract: Graphs are the most powerful, expressive and convenient data structures but there is a lack of efficient computational tools and algorithms for processing them. The embedding of graphs into numeric vector spaces permits them to access the state-of-the-art computational efficient statistical models and tools. In this paper we take forward our work on explicit graph embedding and present an improvement to our earlier proposed method, named “fuzzy multilevel graph embedding – FMGE”, through feature selection technique. FMGE achieves the embedding of attributed graphs into low dimensional vector spaces by performing a multilevel analysis of graphs and extracting a set of global, structural and elementary level features. Feature selection permits FMGE to select the subset of most discriminating features and to discard the confusing ones for underlying graph dataset. Experimental results for graph classification experimentation on IAM letter, GREC and fingerprint graph databases, show improvement in the performance of FMGE.

Abstract: This paper introduces a new facet of social media, namely that depicting social interaction. More concretely, we address this problem from the perspective of nonverbal behavior-based analysis of competitive meetings. For our study, we made use of “The Apprentice” reality TV show, which features a competition for a real, highly paid corporate job. Our analysis is centered around two tasks regarding a person's role in a meeting: predicting the person with the highest status, and predicting the fired candidates. We address this problem by adopting both supervised and unsupervised strategies. The current study was carried out using nonverbal audio cues. Our approach is based only on the nonverbal interaction dynamics during the meeting without relying on the spoken words. The analysis is based on two types of data: individual and relational measures. Results obtained from the analysis of a full season of the show are promising (up to 85.7% of accuracy in the first case and up to 92.8% in the second case). Our approach has been conveniently compared with the Influence Model, demonstrating its superiority.

Abstract: Cardiac magnetic resonance imaging (Cardiac MRI) has become a gold standard diagnostic technique for the assessment of cardiac mechanics, allowing the non-invasive calculation of left ventric- ular long axis longitudinal shortening (LVLS) and absolute myocardial torsion (AMT) between basal and apical left ventricular slices, a movement directly related to the helicoidal anatomic disposition of the myocardial fibers. The aim of this study is to determine AMT and LVLS behaviour and normal values from a group of healthy subjects. A group of 21 healthy volunteers (15 males) (age: 23–55 y.o., mean:30.7 ± 7.5) were prospectively included in an obser- vational study by Cardiac MRI. Left ventricular rotation (degrees) was calculated by custom-made software (Harmonic Phase Flow) in consecutive LV short axis planes tagged cine-MRI sequences. AMT was determined from the difference between basal and apical planes LV rotations. LVLS (%) was determined from the LV longitudinal and horizontal axis cine-MRI images. All the 21 cases studied were interpretable, although in three cases the value of the LV apical rotation could not be determined. The mean rotation of the basal and apical planes at end-systole were -3.71° ± 0.84° and 6.73° ± 1.69° (n:18) respectively, resulting in a LV mean AMT of 10.48° ± 1.63° (n:18). End-systolic mean LVLS was 19.07 ± 2.71%. Cardiac MRI allows for the calculation of AMT and LVLS, fundamental functional components of the ventricular twist mechanics conditioned, in turn, by the anatomical helical layout of the myocardial fibers. These values provide complementary information about systolic ventricular function in relation to the traditional parameters used in daily practice.

Abstract: In this article, a novel technique for user’s authentication and verification using gait as a biometric unobtrusive pattern is proposed. The method is based on a two stages pipeline. First, a general activity recognition classifier is personalized for an specific user using a small sample of her/his walking pattern. As a result, the system is much more selective with respect to the new walking pattern. A second stage verifies whether the user is an authorized one or not. This stage is defined as a one-class classification problem. In order to solve this problem, a four-layer architecture is built around the geometric concept of convex hull. This architecture allows to improve robustness to outliers, modeling non-convex shapes, and to take into account temporal coherence information. Two different scenarios are proposed as validation with two different wearable systems. First, a custom high-performance wearable system is built and used in a free environment. A second dataset is acquired from an Android-based commercial device in a ‘wild’ scenario with rough terrains, adversarial conditions, crowded places and obstacles. Results on both systems and datasets are very promising, reducing the verification error rates by an order of magnitude with respect to the state-of-the-art technologies.