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Author Debora Gil; Aura Hernandez-Sabate; Mireia Burnat; Steven Jansen; Jordi Martinez-Vilalta
Title Structure-Preserving Smoothing of Biomedical Images Type Conference Article
Year 2009 Publication 13th International Conference on Computer Analysis of Images and Patterns Abbreviated Journal
Volume 5702 Issue Pages 427-434
Keywords non-linear smoothing; differential geometry; anatomical structures segmentation; cardiac magnetic resonance; computerized tomography.
Abstract Smoothing of biomedical images should preserve gray-level transitions between adjacent tissues, while restoring contours consistent with anatomical structures. Anisotropic diffusion operators are based on image appearance discontinuities (either local or contextual) and might fail at weak inter-tissue transitions. Meanwhile, the output of block-wise and morphological operations is prone to present a block structure due to the shape and size of the considered pixel neighborhood. In this contribution, we use differential geometry concepts to define a diffusion operator that restricts to image consistent level-sets. In this manner, the final state is a non-uniform intensity image presenting homogeneous inter-tissue transitions along anatomical structures, while smoothing intra-structure texture. Experiments on different types of medical images (magnetic resonance, computerized tomography) illustrate its benefit on a further process (such as segmentation) of images.
Address Münster, Germany
Corporate Author Thesis
Publisher Springer Berlin Heidelberg Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title LNCS
Series Volume Series Issue Edition
ISSN 0302-9743 ISBN 978-3-642-03766-5 Medium
Area Expedition Conference CAIP
Notes IAM Approved no
Call Number (down) IAM @ iam @ GHB2009 Serial 1527
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Author Debora Gil; Jaume Garcia; Manuel Vazquez; Ruth Aris; Guillaume Houzeaux
Title Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function Type Conference Article
Year 2008 Publication 8th World Congress on Computational Mechanichs (WCCM8)/5th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2008) Abbreviated Journal
Volume Issue Pages
Keywords Left Ventricle; Electromechanical Models; Image Processing; Magnetic Resonance.
Abstract Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality . In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp. We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment. The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted. The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model.
Address
Corporate Author Thesis
Publisher Place of Publication Venezia (Italia) Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN B-31470-08 ISBN Medium
Area Expedition Conference
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGV2008c Serial 1521
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Author Debora Gil; Jaume Garcia; Mariano Vazquez; Ruth Aris; Guilleaume Houzeaux
Title Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function Type Conference Article
Year 2008 Publication 8th World Congress on Computational Mechanichs (WCCM8) Abbreviated Journal
Volume Issue Pages
Keywords Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance.
Abstract Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model.
Address Venice; Italy
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 9788496736559 Medium
Area Expedition Conference
Notes IAM; Approved no
Call Number (down) IAM @ iam @ GGV2008b Serial 993
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Author Debora Gil; Jordi Gonzalez; Gemma Sanchez (eds)
Title Computer Vision: Advances in Research and Development Type Book Whole
Year 2007 Publication Proceedings of the 2nd CVC International Workshop Abbreviated Journal
Volume Issue Pages
Keywords
Abstract
Address
Corporate Author Thesis
Publisher UAB Place of Publication Bellaterra (Spain) Editor Debora Gil; Jordi Gonzalez; Gemma Sanchez
Language Summary Language Original Title
Series Editor Series Title 2 Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 978-84-935251-4-9 Medium
Area Expedition Conference
Notes IAM; ISE; DAG Approved no
Call Number (down) IAM @ iam @ GGS2007 Serial 1493
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Author Sandra Pujades;Francesc Carreras;Manuel Ballester; Jaume Garcia; Debora Gil
Title A Normalized Parametric Domain for the Analysis of the Left Ventricular Function Type Conference Article
Year 2008 Publication Proceedings of the Third International Conference on Computer Vision Theory and Applications (VISAPP’08) Abbreviated Journal
Volume 1 Issue Pages 267-274
Keywords Helical Ventricular Myocardial Band; Myocardial Fiber; Tagged Magnetic Resonance; HARP; Optical Flow Variational Framework; Gabor Filters; B-Splines.
Abstract Impairment of left ventricular (LV) contractility due to cardiovascular diseases is reflected in LV motion patterns. The mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fiber. The helical ventricular myocardial band (HVMB) concept describes the myocardial muscle as a unique muscular band that twists in space in a non homogeneous fashion. The 3D anisotropy of the ventricular band fibers suggests a regional analysis of the heart motion. Computation of normality models of such motion can help in the detection and localization of any cardiac disorder. In this paper we introduce, for the first time, a normalized parametric domain that allows comparison of the left ventricle motion across patients. We address, both, extraction of the LV motion from Tagged Magnetic Resonance images, as well as, defining a mapping of the LV to a common normalized domain. Extraction of normality motion patterns from 17 healthy volunteers shows the clinical potential of our LV parametrization.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM; Approved no
Call Number (down) IAM @ iam @ GGP2008 Serial 1627
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Author Jaume Garcia; Debora Gil; Luis Badiella; Aura Hernandez-Sabate; Francesc Carreras; Sandra Pujades; Enric Marti
Title A Normalized Framework for the Design of Feature Spaces Assessing the Left Ventricular Function Type Journal Article
Year 2010 Publication IEEE Transactions on Medical Imaging Abbreviated Journal TMI
Volume 29 Issue 3 Pages 733-745
Keywords
Abstract A through description of the left ventricle functionality requires combining complementary regional scores. A main limitation is the lack of multiparametric normality models oriented to the assessment of regional wall motion abnormalities (RWMA). This paper covers two main topics involved in RWMA assessment. We propose a general framework allowing the fusion and comparison across subjects of different regional scores. Our framework is used to explore which combination of regional scores (including 2-D motion and strains) is better suited for RWMA detection. Our statistical analysis indicates that for a proper (within interobserver variability) identification of RWMA, models should consider motion and extreme strains.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0278-0062 ISBN Medium
Area Expedition Conference
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGH2010b Serial 1507
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Author Jaume Garcia; Debora Gil; Aura Hernandez-Sabate
Title Endowing Canonical Geometries to Cardiac Structures Type Book Chapter
Year 2010 Publication Statistical Atlases And Computational Models Of The Heart Abbreviated Journal
Volume 6364 Issue Pages 124-133
Keywords
Abstract International conference on Cardiac electrophysiological simulation challenge
In this paper, we show that canonical (shape-based) geometries can be endowed to cardiac structures using tubular coordinates defined over their medial axis. We give an analytic formulation of these geometries by means of B-Splines. Since B-Splines present vector space structure PCA can be applied to their control points and statistical models relating boundaries and the interior of the anatomical structures can be derived. We demonstrate the applicability in two cardiac structures, the 3D Left Ventricular volume, and the 2D Left-Right ventricle set in 2D Short Axis view.
Address
Corporate Author Thesis
Publisher Springer Berlin / Heidelberg Place of Publication Editor Camara, O.; Pop, M.; Rhode, K.; Sermesant, M.; Smith, N.; Young, A.
Language Summary Language Original Title
Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGH2010b Serial 1515
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Author Debora Gil; Jaume Garcia; Aura Hernandez-Sabate; Enric Marti
Title Manifold parametrization of the left ventricle for a statistical modelling of its complete anatomy Type Conference Article
Year 2010 Publication 8th Medical Imaging Abbreviated Journal
Volume 7623 Issue 762304 Pages 304
Keywords
Abstract Distortion of Left Ventricle (LV) external anatomy is related to some dysfunctions, such as hypertrophy. The architecture of myocardial fibers determines LV electromechanical activation patterns as well as mechanics. Thus, their joined modelling would allow the design of specific interventions (such as peacemaker implantation and LV remodelling) and therapies (such as resynchronization). On one hand, accurate modelling of external anatomy requires either a dense sampling or a continuous infinite dimensional approach, which requires non-Euclidean statistics. On the other hand, computation of fiber models requires statistics on Riemannian spaces. Most approaches compute separate statistical models for external anatomy and fibers architecture. In this work we propose a general mathematical framework based on differential geometry concepts for computing a statistical model including, both, external and fiber anatomy. Our framework provides a continuous approach to external anatomy supporting standard statistics. We also provide a straightforward formula for the computation of the Riemannian fiber statistics. We have applied our methodology to the computation of complete anatomical atlas of canine hearts from diffusion tensor studies. The orientation of fibers over the average external geometry agrees with the segmental description of orientations reported in the literature.
Address
Corporate Author Thesis
Publisher SPIE Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference SPIE
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGH2010a Serial 1522
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Author Jaume Garcia; Debora Gil; Francesc Carreras ; Sandra Pujades; R.Leta; Xavier Alomar; Guillem Pons-LLados
Title Un Model 3D del Ventricle Esquerre Integrant Anatomia i Funcionalitat Type Conference Article
Year 2008 Publication XX Congrés de la Societat Catalana de Cardiologia, Actes del Congres Abbreviated Journal
Volume Issue Pages 122
Keywords
Abstract Els canvis en la dinàmica del Ventricle Esquerre (VE) reflecteixen la majoria de malalties cardiovasculars . Els avenços en imatge mèdica han impulsat la recerca en models i simulacions de la dinàmica 3D del VE . La majoria dels models existents sols consideren l’anatomia externa del VE i no permeten una avaluació de l’acoblament electromecànic . Donat que la mecànica d’un muscle depèn de la orientació de les seves fibres, un model realista hauria d’incloure la disposició espacial de la banda ventricular helicoidal (BVH) .
Proposem desenvolupar un model del VE adaptat a cada pacient que integri, per primer cop, l’anatomia de la banda ventricular, l’anatomia externa del VE i la seva funcionalitat, per a una millor determinació del patró d’activació electromecànica
Address
Corporate Author Thesis
Publisher Place of Publication Barcelona Editor
Language catalan Summary Language catalan Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGC2008c Serial 1504
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Author Jaume Garcia; Debora Gil; Francesc Carreras; Sandra Pujades; R.Leta; Xavier Alomar; Guillem Pons-LLados
Title Patrons de Normalitat Regional per la Valoració de la Funció del Ventricle Esquerre Type Conference Article
Year 2008 Publication XX Congrés de la Societat Catalana de Cardiologia Abbreviated Journal
Volume Issue Pages 60
Keywords
Abstract Les malalties cardiovasculars afecten les propietats contràctils de la banda ventricular i provoquen una variació de la funció del Ventricle Esquerre (VE) . Només els indicadors locals (strains, la deformació del teixit) són capaços de detectar anomalies en territoris específics del VE . Patrons de normalitat regionals d’aquests paràmetres serien d’utilitat a l’hora de valorar-ne la funció .
Presentem un Domini Paramètric Normalitzat (DPN) que permet comparar dades de diferents pacients i definir Patrons de Normalitat Regional (PNR)
Address
Corporate Author Thesis
Publisher Place of Publication Barcelona Editor
Language catalan Summary Language catalan Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM; Approved no
Call Number (down) IAM @ iam @ GGC2008b Serial 1503
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Author Jaume Garcia; Debora Gil; Sandra Pujades; Francesc Carreras
Title A Variational Framework for Assessment of the Left Ventricle Motion Type Journal Article
Year 2008 Publication International Journal Mathematical Modelling of Natural Phenomena Abbreviated Journal
Volume 3 Issue 6 Pages 76-100
Keywords Key words: Left Ventricle Dynamics, Ventricular Torsion, Tagged Magnetic Resonance, Motion Tracking, Variational Framework, Gabor Transform.
Abstract Impairment of left ventricular contractility due to cardiovascular diseases is reflected in left ventricle (LV) motion patterns. An abnormal change of torsion or long axis shortening LV values can help with the diagnosis and follow-up of LV dysfunction. Tagged Magnetic Resonance (TMR) is a widely spread medical imaging modality that allows estimation of the myocardial tissue local deformation. In this work, we introduce a novel variational framework for extracting the left ventricle dynamics from TMR sequences. A bi-dimensional representation space of TMR images given by Gabor filter banks is defined. Tracking of the phases of the Gabor response is combined using a variational framework which regularizes the deformation field just at areas where the Gabor amplitude drops, while restoring the underlying motion otherwise. The clinical applicability of the proposed method is illustrated by extracting normality models of the ventricular torsion from 19 healthy subjects.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGC2008a Serial 1058
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Author Jaume Garcia; Debora Gil; Francesc Carreras; Sandra Pujades; R.Leta
Title Modelització 4-Dimensional de la Funció Siatólica del Ventricle Esquerre Type Conference Article
Year 2007 Publication XIX Congrés de la Societat Catalana de Cardiologia de Barcelona Abbreviated Journal
Volume Issue Pages 133-134
Keywords
Abstract L’evolució tecnològica en el tractament de les imatges mèdiques permet reconstruir, amb el software apropiat, imatges tridimensionals de les estructures cardiovasculars i dotar-les de moviment. Les imatges 4D resultants faciliten l’estudi de la fisiopatologia de la insuficiència cardíaca en base als transtorns de l’activació electromecànica ventricular, el que pot ser d’interès en el procés de selecció de pacients candidats a teràpies de resincronització. Presentem els resultats preliminars de la reconstrucció 4D del ventricle esquerre (VE) a partir de les seqüències de tagging miocàrdic del VE.
Address
Corporate Author Thesis
Publisher Place of Publication Barcelona (Spain) Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGC2007 Serial 1505
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Author Debora Gil; Agnes Borras; Manuel Ballester; Francesc Carreras; Ruth Aris; Manuel Vazquez; Enric Marti; Ferran Poveda
Title MIOCARDIA: Integrating cardiac function and muscular architecture for a better diagnosis Type Conference Article
Year 2011 Publication 14th International Symposium on Applied Sciences in Biomedical and Communication Technologies Abbreviated Journal
Volume Issue Pages
Keywords
Abstract Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization.
Address Barcelona; Spain
Corporate Author Association for Computing Machinery Thesis
Publisher Place of Publication Barcelona, Spain Editor Association for Computing Machinery
Language english Summary Language english Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 978-1-4503-0913-4 Medium
Area Expedition Conference ISABEL
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGB2011 Serial 1691
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Author Jaume Garcia; Debora Gil; A.Bajo; M.J.Ledesma-Carbayo; C.SantaMarta
Title Influence of the temporal resolution on the quantification of displacement fields in cardiac magnetic resonance tagged images Type Conference Article
Year 2008 Publication Proc. Computers in Cardiology Abbreviated Journal
Volume 35 Issue Pages 785-788
Keywords
Abstract It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possible. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%.
Address
Corporate Author Thesis
Publisher Place of Publication Editor Alan Murray
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM Approved no
Call Number (down) IAM @ iam @ GGB2008 Serial 1508
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Author Jaume Garcia; Debora Gil; Joel Barajas; Francesc Carreras; Sandra Pujades; Petia Radeva
Title Characterization of ventricular torsion in healthy subjects using Gabor filters and a variational framework Type Conference Article
Year 2006 Publication Proc. Computers in Cardiology Abbreviated Journal
Volume Issue Pages 877-880
Keywords
Abstract In this work, we present a fully automated method for tissue deformation estimation in tagged magnetic resonance images (TMRI). Gabor filter banks, tuned independently for each left ventricle level, provide optimally filtered complex images which phase remains constant along the cardiac cycle. This fact can be thought as the brightness constancy condition required by classical optical flow (OF) methods. Pairs of these filtered sequences, together with a variational formulation are used in a second step to obtain dense continuous deformation maps that we call Harmonic Phase Flow. This method has been used to determine reference values of ventricular torsion (VT) in a set of 8 healthy volunteers. The results encourage the use of VT as a useful parameter for ventricular function assessment in clinical routine.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM;MILAB Approved no
Call Number (down) IAM @ iam @ GGB2006a Serial 1509
Permanent link to this record