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Author Oriol Rodriguez-Leor; Josefina Mauri; Eduard Fernandez-Nofrerias; Vicente de Valle; E. Garcia; A. Barrios; Debora Gil; Petia Radeva
Title Analysis of the changes in angiography local grey-level values to determine myocardial perfusion Type Conference Article
Year 2006 Publication World Congress of Cardiology Abbreviated Journal
Volume Issue Pages 862
Keywords
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Barcelona (Spain) Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM;MILAB Approved no
Call Number (down) IAM @ iam @ RMF2006 Serial 1644
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Author Debora Gil; Aura Hernandez-Sabate; Antoni Carol; Oriol Rodriguez; Petia Radeva
Title A Deterministic-Statistic Adventitia Detection in IVUS Images Type Conference Article
Year 2005 Publication ESC Congress Abbreviated Journal
Volume Issue Pages
Keywords Electron microscopy; Unbending; 2D crystal; Interpolation; Approximation
Abstract Plaque analysis in IVUS planes needs accurate intima and adventitia models. Large variety in adventitia descriptors difficulties its detection and motivates using a classification strategy for selecting points on the structure. Whatever the set of descriptors used, the selection stage suffers from fake responses due to noise and uncompleted true curves. In order to smooth background noise while strengthening responses, we apply a restricted anisotropic filter that homogenizes grey levels along the image significant structures. Candidate points are extracted by means of a simple semi supervised adaptive classification of the filtered image response to edge and calcium detectors. The final model is obtained by interpolating the former line segments with an anisotropic contour closing technique based on functional extension principles.
Address Stockholm; Sweden; September 2005
Corporate Author Thesis
Publisher Place of Publication ,Sweden (EU) Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference ESC
Notes IAM;MILAB Approved no
Call Number (down) IAM @ iam @ RMF2005a Serial 1523
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Author Debora Gil; Aura Hernandez-Sabate; Antoni Carol; Oriol Rodriguez; Petia Radeva
Title A Deterministic-Statistic Adventitia Detection in IVUS Images Type Conference Article
Year 2005 Publication 3rd International workshop on International Workshop on Functional Imaging and Modeling of the Heart Abbreviated Journal
Volume Issue Pages 65-74
Keywords Electron microscopy; Unbending; 2D crystal; Interpolation; Approximation
Abstract Plaque analysis in IVUS planes needs accurate intima and adventitia models. Large variety in adventitia descriptors difficulties its detection and motivates using a classification strategy for selecting points on the structure. Whatever the set of descriptors used, the selection stage suffers from fake responses due to noise and uncompleted true curves. In order to smooth background noise while strengthening responses, we apply a restricted anisotropic filter that homogenizes grey levels along the image significant structures. Candidate points are extracted by means of a simple semi supervised adaptive classification of the filtered image response to edge and calcium detectors. The final model is obtained by interpolating the former line segments with an anisotropic contour closing technique based on functional extension principles.
Address Barcelona; June 2005
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference FIMH
Notes IAM;MILAB Approved no
Call Number (down) IAM @ iam @ RMF2005 Serial 1524
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Author Oriol Rodriguez-Leor; Josefina Mauri; Eduard Fernandez-Nofrerias; Antonio Tovar; Vicente del Valle; Aura Hernandez-Sabate; Debora Gil; Petia Radeva
Title Utilización de la Estructura de los Campos Vectoriales para la Detección de la Adventicia en Imágenes de Ecografía Intracoronaria Type Journal Article
Year 2004 Publication Revista Internacional de Enfermedades Cardiovasculares Revista Española de Cardiología Abbreviated Journal
Volume 57 Issue 2 Pages 100
Keywords
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference SEC
Notes IAM;MILAB Approved no
Call Number (down) IAM @ iam @ RMF2004 Serial 1642
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Author Oriol Rodriguez-Leor; Josefina Mauri; Eduard Fernandez-Nofrerias; C. Garcia; R. Villuendas; Vicente del Valle; Debora Gil; Petia Radeva
Title Reconstruction of a spatio-temporal model of the intima layer from intravascular ultrasound sequences Type Journal Article
Year 2003 Publication European Heart Journal Abbreviated Journal
Volume Issue Pages
Keywords
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference ESC Congress
Notes IAM;MILAB Approved no
Call Number (down) IAM @ iam @ RMF2003c Serial 1641
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Author Oriol Rodriguez-Leor; Josefina Mauri; Eduard Fernandez-Nofrerias; M. Gomez; Antonio Tovar; L. Cano; C. Diego; Carme Julia; Vicente del Valle; Debora Gil; Petia Radeva
Title Ecografia Intracoronària: Segmentació Automàtica de area de la llum Type Conference Article
Year 2002 Publication XXXVIII Congreso Nacional de la Sociedad Española de Cardiología. Abbreviated Journal
Volume Issue Pages
Keywords
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM;ADAS;MILAB Approved no
Call Number (down) IAM @ iam @ RMF2002 Serial 1638
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Author Petia Radeva; Amir Amini; Jintao Huang; Enric Marti
Title Deformable B-Solids: application for localization and tracking of MRI-SPAMM data Type Report
Year 1996 Publication CVC Technical Report Abbreviated Journal
Volume Issue 8 Pages
Keywords
Abstract To date, MRI-SPAMM data from different image slices have been analyzed independently. In this paper, we propose an approach for 3D tag localization and tracking of SPAMM data by a novel deformable B-solid. The solid is defined in terms of a 3D tensor product B-spline. The isoparametric curves of the B-spline solid have special importance. These are termed implicit snakes as they deform under image forces from tag lines in different image slices. The localization and tracking of tag lines is performed under constraints of continuity and smoothness of the B-solid. The framework unifies the problems of localization, and displacement fitting and interpolation into the same procedure utilizing B-spline bases for interpolation. To track motion from boundaries and restrict image forces to the myocardium, a volumetric model is employed as a pair of coupled endocardial and epicardial B-spline surfaces. To recover deformations in the LV an energy-minimization problem is posed where both tag and ...
Address
Corporate Author Thesis
Publisher CVC (UAB) Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes MILAB;IAM Approved no
Call Number (down) IAM @ iam @ RHM1996 Serial 1631
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Author David Roche; Debora Gil; Jesus Giraldo
Title Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? Type Book Chapter
Year 2014 Publication G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology Abbreviated Journal
Volume 796 Issue 3 Pages 159-181
Keywords β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model
Abstract Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.
Address
Corporate Author Thesis
Publisher Springer Netherlands Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0065-2598 ISBN 978-94-007-7422-3 Medium
Area Expedition Conference
Notes IAM; 600.075 Approved no
Call Number (down) IAM @ iam @ RGG2014 Serial 2197
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Author David Roche; Debora Gil; Jesus Giraldo
Title Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models Type Journal Article
Year 2013 Publication British Journal of Pharmacology Abbreviated Journal BJP
Volume 169 Issue 6 Pages 1189-202
Keywords
Abstract Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM; 600.044; 605.203 Approved no
Call Number (down) IAM @ iam @ RGG2013b Serial 2195
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Author David Roche; Debora Gil; Jesus Giraldo
Title Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, Type Journal Article
Year 2013 Publication Drug Discovery Today Abbreviated Journal DDT
Volume 18 Issue 7-8 Pages 365-371
Keywords
Abstract The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.
Address
Corporate Author Thesis
Publisher Elsevier Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM; 600.057; 600.054 Approved no
Call Number (down) IAM @ iam @ RGG2013a Serial 2190
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Author David Roche; Debora Gil; Jesus Giraldo
Title Assessing agonist efficacy in an uncertain Em world Type Conference Article
Year 2012 Publication 40th Keystone Symposia on mollecular and celular biology Abbreviated Journal
Volume Issue Pages 79
Keywords
Abstract The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
Address Fairmont Banff Springs, Banff, Alberta, Canada
Corporate Author Keystone Symposia Thesis
Publisher Keystone Symposia Place of Publication Editor A. Christopoulus and M. Bouvier
Language english Summary Language english Original Title
Series Editor Keystone Symposia Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference KSMCB
Notes IAM Approved no
Call Number (down) IAM @ iam @ RGG2012 Serial 1855
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Author David Roche; Debora Gil; Jesus Giraldo
Title Using statistical inference for designing termination conditions ensuring convergence of Evolutionary Algorithms Type Conference Article
Year 2011 Publication 11th European Conference on Artificial Life Abbreviated Journal
Volume Issue Pages
Keywords
Abstract A main challenge in Evolutionary Algorithms (EAs) is determining a termination condition ensuring stabilization close to the optimum in real-world applications. Although for known test functions distribution-based quantities are good candidates (as far as suitable parameters are used), in real-world problems an open question still remains unsolved. How can we estimate an upper-bound for the termination condition value ensuring a given accuracy for the (unknown) EA solution?
We claim that the termination problem would be fully solved if we defined a quantity (depending only on the EA output) behaving like the solution accuracy. The open question would be, then, satisfactorily answered if we had a model relating both quantities, since accuracy could be predicted from the alternative quantity. We present a statistical inference framework addressing two topics: checking the correlation between the two quantities and defining a regression model for predicting (at a given confidence level) accuracy values from the EA output.
Address Paris, France
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference ECAL
Notes IAM; Approved no
Call Number (down) IAM @ iam @ RGG2011b Serial 1678
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Author David Roche; Debora Gil; Jesus Giraldo
Title An inference model for analyzing termination conditions of Evolutionary Algorithms Type Conference Article
Year 2011 Publication 14th Congrès Català en Intel·ligencia Artificial Abbreviated Journal
Volume Issue Pages 216-225
Keywords Evolutionary Computation Convergence, Termination Conditions, Statistical Inference
Abstract In real-world problems, it is mandatory to design a termination condition for Evolutionary Algorithms (EAs) ensuring stabilization close to the unknown optimum. Distribution-based quantities are good candidates as far as suitable parameters are used. A main limitation for application to real-world problems is that such parameters strongly depend on the topology of the objective function, as well as, the EA paradigm used.
We claim that the termination problem would be fully solved if we had a model measuring to what extent a distribution-based quantity asymptotically behaves like the solution accuracy. We present a regression-prediction model that relates any two given quantities and reports if they can be statistically swapped as termination conditions. Our framework is applied to two issues. First, exploring if the parameters involved in the computation of distribution-based quantities influence their asymptotic behavior. Second, to what extent existing distribution-based quantities can be asymptotically exchanged for the accuracy of the EA solution.
Address Lleida, Catalonia (Spain)
Corporate Author Associació Catalana Intel·ligència Artificial Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 978-1-60750-841-0 Medium
Area Expedition Conference CCIA
Notes IAM Approved no
Call Number (down) IAM @ iam @ RGG2011a Serial 1677
Permanent link to this record
 
 
Author Oriol Rodriguez-Leor; Debora Gil; Eduard Fernandez-Nofrerias; H. Tizon; S. Montserrat; Vicente del Valle; Josefina Mauri
Title Caracterització de la Perfusió Miocàrdica mitjançant anàlisi estadístic de l espectre en l angiografia de contrast Type Conference Article
Year 2007 Publication XIX Congrés de la Societat Catalana de Cardiologia de Barcelona Abbreviated Journal
Volume Issue Pages 130
Keywords
Abstract La valoració de la integritat de la microcirculació coronària aporta informació pronòstica en pacients amb infart agut de miocardi en els que es realitza angioplastia primària. Aquesta valoració és subjectiva i presenta una important variabilitat si no es duta a terme per personal experimentat. Presentem una eina d’anàlisi d’imatge que permet fer una valoració de la microcirculació coronària a partir de seqüències d’angiografia. Hem analitzat les variacions locals en el nivell de gris de la imatge durant la seqüència angiogràfica. Hem identificat els principals fenòmens observats (respiració, batec cardíac, tinció arterial, tinció miocàrdica i soroll radiològic) mitjançant un anàlisi estadístic de l’espectre de Fourier de l’evolució al llarg del temps de la mitja local. Aquest mateix anàlisis permet determinat la influència de cadascun d’ells en la extracció del patró de tinció i selecciona la respiració com el fenomen que més distorsiona el patró de tinció original. Els descriptors proposats s’obtenen fora del rang espectral respiratori. Hem testat la seva capacitat per a detectar els tres fenòmens principals (tinció miocàrdica (MS), tinció arterial (AS) i soroll (NS)) independentment de la respiració. La capacitat de discriminació dels descriptors ha estat valorada mitjançant un mètode de crossvalidation en 30 seqüències d’angiografia. Els descriptors emprats permeten caracteritzar la tinció miocàrdica amb una alta eficiència i fiabilitat. A més no hi ha diferències significatives en l’anàlisi de les seqüències obtingudes amb el pacient respirant amb normalitat o en apnea
Address
Corporate Author Thesis
Publisher Place of Publication Barcelona (Spain) Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM Approved no
Call Number (down) IAM @ iam @ RGF2007 Serial 1639
Permanent link to this record
 
 
Author Oriol Rodriguez-Leor; Debora Gil; Eduard Fernandez-Nofrerias
Title Analisis en los cambios en el nivel de gris en las secuencias angiograficas mediante descriptores estadisticos para determinar la perfusion miocardica Type Journal Article
Year 2006 Publication Revista Española de Cardiología Abbreviated Journal REC
Volume 59 Supl 2-166 Issue 2 Pages 128
Keywords
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes IAM; Approved no
Call Number (down) IAM @ iam @ RGF2006 Serial 1640
Permanent link to this record