Abstract: In this thesis, several methods for the automatic analysis of Intravascular Ultrasound
(IVUS) sequences are presented, aimed at assisting physicians in the diagnosis, the assessment of the intervention and the monitoring of the patients with coronary disease.
The basis for the developed frameworks are machine learning, pattern recognition and
image processing techniques.
First, a novel approach for the automatic detection of vascular bifurcations in
IVUS is presented. The task is addressed as a binary classication problem (identifying bifurcation and non-bifurcation angular sectors in the sequence images). The
multiscale stacked sequential learning algorithm is applied, to take into account the
spatial and temporal context in IVUS sequences, and the results are rened using
a-priori information about branching dimensions and geometry. The achieved performance is comparable to intra- and inter-observer variability.
Then, we propose a novel method for the automatic non-rigid alignment of IVUS
sequences of the same patient, acquired at dierent moments (before and after percutaneous coronary intervention, or at baseline and follow-up examinations). The
method is based on the description of the morphological content of the vessel, obtained by extracting temporal morphological proles from the IVUS acquisitions, by
means of methods for segmentation, characterization and detection in IVUS. A technique for non-rigid sequence alignment – the Dynamic Time Warping algorithm -
is applied to the proles and adapted to the specic clinical problem. Two dierent robust strategies are proposed to address the partial overlapping between frames
of corresponding sequences, and a regularization term is introduced to compensate
for possible errors in the prole extraction. The benets of the proposed strategy
are demonstrated by extensive validation on synthetic and in-vivo data. The results
show the interest of the proposed non-linear alignment and the clinical value of the
method.
Finally, a novel automatic approach for the extraction of the luminal border in
IVUS images is presented. The method applies the multiscale stacked sequential
learning algorithm and extends it to 2-D+T, in a rst classication phase (the identi-
cation of lumen and non-lumen regions of the images), while an active contour model
is used in a second phase, to identify the lumen contour. The method is extended
to the longitudinal dimension of the sequences and it is validated on a challenging
data-set.

Abstract: Writing is one of the most important forms of communication and for centuries, handwriting had been the most reliable way to preserve knowledge. However, despite the recent development of printing houses and electronic devices, handwriting is still broadly used for taking notes, doing annotations, or sketching ideas.
Transferring the ability of understanding handwritten text or recognizing handwritten shapes to computers has been the goal of many researches due to its huge importance for many different fields. However, designing good representations to deal with handwritten shapes, e.g. symbols or words, is a very challenging problem due to the large variability of these kinds of shapes. One of the consequences of working with handwritten shapes is that we need representations to be robust, i.e., able to adapt to large intra-class variability. We need representations to be discriminative, i.e., able to learn what are the differences between classes. And, we need representations to be efficient, i.e., able to be rapidly computed and compared. Unfortunately, current techniques of handwritten shape representation for matching and recognition do not fulfill some or all of these requirements.
Through this thesis we focus on the problem of learning to represent handwritten shapes aimed at retrieval and recognition tasks. Concretely, on the first part of the thesis, we focus on the general problem of representing any kind of handwritten shape. We first present a novel shape descriptor based on a deformable grid that deals with large deformations by adapting to the shape and where the cells of the grid can be used to extract different features. Then, we propose to use this descriptor to learn statistical models, based on the Active Appearance Model, that jointly learns the variability in structure and texture of a given class. Then, on the second part, we focus on a concrete application, the problem of representing handwritten words, for the tasks of word spotting, where the goal is to find all instances of a query word in a dataset of images, and recognition. First, we address the segmentation-free problem and propose an unsupervised, sliding-window-based approach that achieves state-of- the-art results in two public datasets. Second, we address the more challenging multi-writer problem, where the variability in words exponentially increases. We describe an approach in which both word images and text strings are embedded in a common vectorial subspace, and where those that represent the same word are close together. This is achieved by a combination of label embedding and attributes learning, and a common subspace regression. This leads to a low-dimensional, unified representation of word images and strings, resulting in a method that allows one to perform either image and text searches, as well as image transcription, in a unified framework. We evaluate our methods on different public datasets of both handwritten documents and natural images showing results comparable or better than the state-of-the-art on spotting and recognition tasks.

Abstract: The mass irruption of Deep Convolutional Neural Networks (CNNs) in computer vision since 2012 led to a dominance of the image understanding paradigm consisting in an end-to-end fully supervised learning workflow over large-scale annotated datasets. This approach proved to be extremely useful at solving a myriad of classic and new computer vision tasks with unprecedented performance —often, surpassing that of humans—, at the expense of vast amounts of human-labeled data, extensive computational resources and the disposal of all of our prior knowledge on the task at hand. Even though simple transfer learning methods, such as fine-tuning, have achieved remarkable impact, their success when the amount of labeled data in the target domain is small is limited. Furthermore, the non-static nature of data generation sources will often derive in data distribution shifts that degrade the performance of deployed models. As a consequence, there is a growing demand for methods that can exploit elements of prior knowledge and sources of information other than the manually generated ground truth annotations of the images during the network training process, so that they can adapt to new domains that constitute, if not a small data regime, at least a small labeled data regime. This thesis targets such few or no labeled data scenario in three distinct image-to-image mapping learning problems. It contributes with various approaches that leverage our previous knowledge of different elements of the image formation process: We first present a data-efficient framework for both defocus and motion blur detection, based on a model able to produce realistic synthetic local degradations. The framework comprises a self-supervised, a weakly-supervised and a semi-supervised instantiation, depending on the absence or availability and the nature of human annotations, and outperforms fully-supervised counterparts in a variety of settings. Our knowledge on color image formation is then used to gather input and target ground truth image pairs for the RGB to hyperspectral image reconstruction task. We make use of a CNN to tackle this problem, which, for the first time, allows us to exploit spatial context and achieve state-of-the-art results given a limited hyperspectral image set. In our last contribution to the subfield of data-efficient image-to-image transformation problems, we present the novel semi-supervised task of zero-pair cross-view semantic segmentation: we consider the case of relocation of the camera in an end-to-end trained and deployed monocular, fixed-view semantic segmentation system often found in industry. Under the assumption that we are allowed to obtain an additional set of synchronized but unlabeled image pairs of new scenes from both original and new camera poses, we present ZPCVNet, a model and training procedure that enables the production of dense semantic predictions in either source or target views at inference time. The lack of existing suitable public datasets to develop this approach led us to the creation of MVMO, a large-scale Multi-View, Multi-Object path-traced dataset with per-view semantic segmentation annotations. We expect MVMO to propel future research in the exciting under-developed fields of cross-view and multi-view semantic segmentation. Last, in a piece of applied research of direct application in the context of process monitoring of an Electric Arc Furnace (EAF) in a steelmaking plant, we also consider the problem of simultaneously estimating the temperature and spectral emissivity of distant hot emissive samples. To that end, we design our own capturing device, which integrates three point spectrometers covering a wide range of the Ultra-Violet, visible, and Infra-Red spectra and is capable of registering the radiance signal incoming from an 8cm diameter spot located up to 20m away. We then define a physically accurate radiative transfer model that comprises the effects of atmospheric absorbance, of the optical system transfer function, and of the sample temperature and spectral emissivity themselves. We solve this inverse problem without the need for annotated data using a probabilistic programming-based Bayesian approach, which yields full posterior distribution estimates of the involved variables that are consistent with laboratory-grade measurements.

Abstract: The comprehension of animal behavior, especially human behavior, is one of the most ancient and studied problems since the beginning of civilization. The big list of factors that interact to determine a person action require the collaboration of different disciplines, such as psichology, biology, or sociology. In the last years the analysis of human behavior has received great attention also from the computer vision community, given the latest advances in the acquisition of human motion data from image sequences.
Despite the increasing availability of that data, there still exists a gap towards obtaining a conceptual representation of the obtained observations. Human behavior analysis is based on a qualitative interpretation of the results, and therefore the assignment of concepts to quantitative data is linked to a certain ambiguity.
This Thesis tackles the problem of obtaining a proper representation of human behavior in the contexts of computer vision and animation. On the one hand, a good behavior model should permit the recognition and explanation the observed activity in image sequences. On the other hand, such a model must allow the generation of new synthetic instances, which model the behavior of virtual agents.
First, we propose methods to automatically learn the models from observations. Given a set of quantitative results output by a vision system, a normal behavior model is learnt. This results provides a tool to determine the normality or abnormality of future observations. However, machine learning methods are unable to provide a richer description of the observations. We confront this problem by means of a new method that incorporates prior knowledge about the enviornment and about the expected behaviors. This framework, formed by the reasoning engine FMTL and the modeling tool SGT allows the generation of conceptual descriptions of activity in new image sequences. Finally, we demonstrate the suitability of the proposed framework to simulate behavior of virtual agents, which are introduced into real image sequences and interact with observed real agents, thereby easing the generation of augmented reality sequences.
The set of approaches presented in this Thesis has a growing set of potential applications. The analysis and description of behavior in image sequences has its principal application in the domain of smart video--surveillance, in order to detect suspicious or dangerous behaviors. Other applications include automatic sport commentaries, elderly monitoring, road traffic analysis, and the development of semantic video search engines. Alternatively, behavioral virtual agents allow to simulate accurate real situations, such as fires or crowds. Moreover, the inclusion of virtual agents into real image sequences has been widely deployed in the games and cinema industries.

Abstract: The transcription of sheet music into some machine-readable format can be carried out manually. However, the complexity of music notation inevitably leads to burdensome software for music score editing, which makes the whole process
very time-consuming and prone to errors. Consequently, automatic transcription
systems for musical documents represent interesting tools.
Document analysis is the subject that deals with the extraction and processing
of documents through image and pattern recognition. It is a branch of computer
vision. Taking music scores as source, the field devoted to address this task is
known as Optical Music Recognition (OMR). Typically, an OMR system takes an
image of a music score and automatically extracts its content into some symbolic
structure such as MEI or MusicXML.
In this dissertation, we have investigated different methods for recognizing a
single staff section (e.g. scores for violin, flute, etc.), much in the same way as most text recognition research focuses on recognizing words appearing in a given line image. These methods are based in two different methodologies. On the one hand, we present two methods based on Recurrent Neural Networks, in particular, the
Long Short-Term Memory Neural Network. On the other hand, a method based on Sequence to Sequence models is detailed.
Music context is needed to improve the OMR results, just like language models
and dictionaries help in handwriting recognition. For example, syntactical rules
and grammars could be easily defined to cope with the ambiguities in the rhythm.
In music theory, for example, the time signature defines the amount of beats per
bar unit. Thus, in the second part of this dissertation, different methodologies
have been investigated to improve the OMR recognition. We have explored three
different methods: (a) a graphic tree-structure representation, Dendrograms, that
joins, at each level, its primitives following a set of rules, (b) the incorporation of Language Models to model the probability of a sequence of tokens, and (c) graph neural networks to analyze the music scores to avoid meaningless relationships between music primitives.
Finally, to train all these methodologies, and given the method-specificity of
the datasets in the literature, we have created four different music datasets. Two of them are synthetic with a modern or old handwritten appearance, whereas the
other two are real handwritten scores, being one of them modern and the other
old.

Abstract: Single image super-resolution (SISR) is an important task in image processing which aims to enhance the resolution of imaging systems. Recently, SISR has witnessed great strides with the rapid development of deep learning. Recent advances in SISR are mostly devoted to designing deeper and wider networks to enhance their representation learning capacity. However, as the depth of networks increases, deep learning-based methods are faced with the challenge of computational complexity in practice. Moreover, most existing methods rarely leverage the intermediate features and also do not discriminate the computation of features by their frequencial components, thereby achieving relatively low performance. Aside from the aforementioned problems, another desired ability is to upsample images to arbitrary scales using a single model. Most current SISR methods train a dedicated model for each target resolution, losing generality and increasing memory requirements. In this thesis, we address the aforementioned issues and propose solutions to them: i) We present a novel frequency-based enhancement block which treats different frequencies in a heterogeneous way and also models inter-channel dependencies, which consequently enrich the output feature. Thus it helps the network generate more discriminative representations by explicitly recovering finer details. ii) We introduce OverNet which contains two main parts: a lightweight feature extractor that follows a novel recursive framework of skip and dense connections to reduce low-level feature degradation, and an overscaling module that generates an accurate SR image by internally constructing an overscaled intermediate representation of the output features. Then, to solve the problem of reconstruction at arbitrary scale factors, we introduce a novel multi-scale loss, that allows the simultaneous training of all scale factors using a single model. iii) We propose a directional variance attention network which leverages a novel attention mechanism to enhance features in different channels and spatial regions. Moreover, we introduce a novel procedure for using attention mechanisms together with residual blocks to facilitate the preservation of finer details. Finally, we demonstrate that our approaches achieve considerably better performance than previous state-of-the-art methods, in terms of both quantitative and visual quality.

Abstract: Colorectal cancer is the fourth most common cause of cancer death worldwide and its survival rate depends on the stage in which it is detected on hence the necessity for an early colon screening. There are several screening techniques but colonoscopy is still nowadays the gold standard, although it has some drawbacks such as the miss rate. Our contribution, in the field of intelligent systems for colonoscopy, aims at providing a polyp localization and a polyp segmentation system based on a model of appearance for polyps. To develop both methods we define a model of appearance for polyps, which describes a polyp as enclosed by intensity valleys. The novelty of our contribution resides on the fact that we include in our model aspects of the image formation and we also consider the presence of other elements from the endoluminal scene such as specular highlights and blood vessels, which have an impact on the performance of our methods. In order to develop our polyp localization method we accumulate valley information in order to generate energy maps, which are also used to guide the polyp segmentation. Our methods achieve promising results in polyp localization and segmentation. As we want to explore the usability of our methods we present a comparative analysis between physicians fixations obtained via an eye tracking device and our polyp localization method. The results show that our method is indistinguishable to novice physicians although it is far from expert physicians.