Abstract: The measure of lumen volume on radial arteries can be used to evaluate the vessel response to different vasodilators. In this paper, we present a framework for automatic lumen segmentation in longitudinal cut images of radial artery from Intravascular ultrasound sequences. The segmentation is tackled as a classification problem where the contextual information is exploited by means of Conditional Random Fields (CRFs). A multi-class classification framework is proposed, and inference is achieved by combining binary CRFs according to the Error-Correcting-Output-Code technique. The results are validated against manually segmented sequences. Finally, the method is compared with other state-of-the-art classifiers.