Abstract: We present a method for automatic struts detection and stent shape estimation in cross-sectional intravascular ultrasound images. A stent shape is first estimated through a comprehensive interpretation of the vessel morphology, performed using a supervised context-aware multi-class classification scheme. Then, the successive strut identification exploits both local appearance and the defined stent shape. The method is tested on 589 images obtained from 80 patients, achieving a F-measure of 74.1% and an averaged distance between manual and automatic struts of 0.10 mm.

Abstract: We present a method for the automatic detection of key frames in Intravascular Ultrasound (IVUS) sequences. The key frames are markers delimiting morphological changes along the vessel. The aim of defining key frames is two-fold: (1) they allow to summarize the content of the pullback into few representative frames; (2) they represent the basis for the automatic detection of clinical events in IVUS. The proposed approach achieved a compression ratio of 0.016 with respect to the original sequence and an average inter-frame distance of 61.76 frame, minimizing the number of missed clinical events.

Abstract: We present ECOC-DRF, a framework where potential functions for Discriminative Random Fields are formulated as an ensemble of classifiers. We introduce the label trick, a technique to express transitions in the pairwise potential as meta-classes. This allows to independently learn any possible transition between labels without assuming any pre-defined model. The Error Correcting Output Codes matrix is used as ensemble framework for the combination of margin classifiers. We apply ECOC-DRF to a large set of classification problems, covering synthetic, natural and medical images for binary and multi-class cases, outperforming state-of-the art in almost all the experiments.

Abstract: The design and the validation of an automatic plaque characterization technique based on Intravascular Ultrasound (IVUS) usually requires a data ground-truth. The histological analysis of post-mortem coronary arteries is commonly assumed as the state-of-the-art process for the extraction of a reliable data-set of atherosclerotic plaques. Unfortunately, the amount of data provided by this technique is usually few, due to the difficulties in collecting post-mortem cases and phenomena of tissue spoiling during histological analysis. In this paper we tackle the process of fusing in-vivo and in-vitro IVUS data starting with the analysis of recently proposed approaches for the creation of an enhanced IVUS data-set; furthermore, we propose a new approach, named pLDS, based on semi-supervised learning with a data selection criterion. The enhanced data-set obtained by each one of the analyzed approaches is used to train a classifier for tissue characterization purposes. Finally, the discriminative power of each classifier is quantitatively assessed and compared by classifying a data-set of validated in-vitro IVUS data.

Abstract: We present a Conditional Random Fields based approach for segmenting Intravascular Ultrasond (IVUS) images. The presented method uses a contextual discriminative graphical model to deal with the presence of distorsions and artifacts in IVUS images, that turns the segmentation of interesting regions into a difficult task. An accurate lumen segmentation on IVUS longitudinal images is achieved.

Abstract: Accurate detection of in-vivo vulnerable plaque in coronary arteries is still an open problem. Recent studies show that it is highly related to tissue structure and composition. Intravascular Ultrasound (IVUS) is a powerful imaging technique that gives a detailed cross-sectional image of the vessel, allowing to explore arteries morphology. IVUS data validation is usually performed by comparing post-mortem (in-vitro) IVUS data and corresponding histological analysis of the tissue. The main drawback of this method is the few number of available case studies and validated data due to the complex procedure of histological analysis of the tissue. On the other hand, IVUS data from in-vivo cases is easy to obtain but it can not be histologically validated. In this work, we propose to enhance the in-vitro training data set by selectively including examples from in-vivo plaques. For this purpose, a Sequential Floating Forward Selection method is reformulated in the context of plaque characterization. The enhanced classifier performance is validated on in-vitro data set, yielding an overall accuracy of 91.59% in discriminating among fibrotic, lipidic and calcified plaques, while reducing the gap between in-vivo and in-vitro data analysis. Experimental results suggest that the obtained classifier could be properly applied on in-vivo plaque characterization and also demonstrate that the common hypothesis of assuming the difference between in-vivo and in-vitro as negligible is incorrect.