|
Miquel Ferrer, Ernest Valveny, F. Serratosa, & Horst Bunke. (2008). Exact Median Graph Computation via Graph Embedding. In 12th International Workshop on Structural and Syntactic Pattern Recognition (Vol. 5324, 15–24). LNCS.
|
Miquel Ferrer, Ernest Valveny, F. Serratosa, I. Bardaji, & Horst Bunke. (2009). Graph-based k-means clustering: A comparison of the set versus the generalized median graph. In 13th International Conference on Computer Analysis of Images and Patterns (Vol. 5702, 342–350). LNCS. Springer Berlin Heidelberg.
Abstract: In this paper we propose the application of the generalized median graph in a graph-based k-means clustering algorithm. In the graph-based k-means algorithm, the centers of the clusters have been traditionally represented using the set median graph. We propose an approximate method for the generalized median graph computation that allows to use it to represent the centers of the clusters. Experiments on three databases show that using the generalized median graph as the clusters representative yields better results than the set median graph.
|
|
Miquel Ferrer, Ernest Valveny, F. Serratosa, K. Riesen, & Horst Bunke. (2008). An Approximate Algorith for Median Graph Computation using Graph Embedding. In 19th International Conference on Pattern Recognition..
|
Miquel Ferrer, Ernest Valveny, F. Serratosa, K. Riesen, & Horst Bunke. (2010). Generalized Median Graph Computation by Means of Graph Embedding in Vector Spaces. PR - Pattern Recognition, 43(4), 1642–1655.
Abstract: The median graph has been presented as a useful tool to represent a set of graphs. Nevertheless its computation is very complex and the existing algorithms are restricted to use limited amount of data. In this paper we propose a new approach for the computation of the median graph based on graph embedding. Graphs are embedded into a vector space and the median is computed in the vector domain. We have designed a procedure based on the weighted mean of a pair of graphs to go from the vector domain back to the graph domain in order to obtain a final approximation of the median graph. Experiments on three different databases containing large graphs show that we succeed to compute good approximations of the median graph. We have also applied the median graph to perform some basic classification tasks achieving reasonable good results. These experiments on real data open the door to the application of the median graph to a number of more complex machine learning algorithms where a representative of a set of graphs is needed.
Keywords: Graph matching; Weighted mean of graphs; Median graph; Graph embedding; Vector spaces
|
|
Miquel Ferrer, F. Serratosa, & A. Sanfeliu. (2005). Synthesis of median spectral graph. In Pattern Recognition and Image Analysis (IbPRIA´05), LNCS, 3523: 139 146.
|
|
Miquel Ferrer, F. Serratosa, & Ernest Valveny. (2007). On the Relation Between the Median Graph and the Maximum Common Subgraph of a Set of Graphs..
|
Miquel Ferrer, I. Bardaji, Ernest Valveny, Dimosthenis Karatzas, & Horst Bunke. (2013). Median Graph Computation by Means of Graph Embedding into Vector Spaces. In Yun Fu, & Yungian Ma (Eds.), Graph Embedding for Pattern Analysis (pp. 45–72). Springer New York.
Abstract: In pattern recognition [8, 14], a key issue to be addressed when designing a system is how to represent input patterns. Feature vectors is a common option. That is, a set of numerical features describing relevant properties of the pattern are computed and arranged in a vector form. The main advantages of this kind of representation are computational simplicity and a well sound mathematical foundation. Thus, a large number of operations are available to work with vectors and a large repository of algorithms for pattern analysis and classification exist. However, the simple structure of feature vectors might not be the best option for complex patterns where nonnumerical features or relations between different parts of the pattern become relevant.
|
|
Miquel Ferrer, Robert Benavente, Ernest Valveny, J. Garcia, Agata Lapedriza, & Gemma Sanchez. (2008). Aprendizaje Cooperativo Aplicado a la Docencia de las Asignaturas de Programacion en Ingenieria Informatica.
|
Mireia Forns-Nadal, Federico Sem, Anna Mane, Laura Igual, Dani Guinart, & Oscar Vilarroya. (2017). Increased Nucleus Accumbens Volume in First-Episode Psychosis. PRN - Psychiatry Research-Neuroimaging, 263, 57–60.
Abstract: Nucleus accumbens has been reported as a key structure in the neurobiology of schizophrenia. Studies analyzing structural abnormalities have shown conflicting results, possibly related to confounding factors. We investigated the nucleus accumbens volume using manual delimitation in first-episode psychosis (FEP) controlling for age, cannabis use and medication. Thirty-one FEP subjects who were naive or minimally exposed to antipsychotics and a control group were MRI scanned and clinically assessed from baseline to 6 months of follow-up. FEP showed increased relative and total accumbens volumes. Clinical correlations with negative symptoms, duration of untreated psychosis and cannabis use were not significant.
|
|
Mireia Sole, Joan Blanco, Debora Gil, Oliver Valero, G. Fonseka, M. Lawrie, et al. (2017). Chromosome Territories in Mice Spermatogenesis: A new three-dimensional methodology of study. In 11th European CytoGenesis Conference.
|
Mireia Sole, Joan Blanco, Debora Gil, G. Fonseka, Richard Frodsham, Francesca Vidal, et al. (2017). Noves perspectives en l estudi de la territorialitat cromosomica de cel·lules germinals masculines: estudis tridimensionals. JBR - Biologia de la Reproduccio, 73–78.
Abstract: In somatic cells, chromosomes occupy specific nuclear regions called chromosome territories which are involved in the
maintenance and regulation of the genome. Preliminary data in male germ cells also suggest the importance of chromosome
territoriality in cell functionality. Nevertheless, the specific characteristics of testicular tissue (presence of different
cell types with different morphological characteristics, in different stages of development and with different ploidy)
makes difficult to achieve conclusive results. In this study we have developed a methodology to approach the threedimensional
study of all chromosome territories in male germ cells from C57BL/6J mice (Mus musculus). The method
includes the following steps: i) Optimized cell fixation to obtain an optimal preservation of the three-dimensionality cell
morphology, ii) Chromosome identification by FISH (Chromoprobe Multiprobe® OctoChrome™ Murine System; Cytocell)
and confocal microscopy (TCS-SP5, Leica Microsystems), iii) Cell type identification by immunofluorescence
iv) Image analysis using Matlab scripts, v) Numerical data extraction related to chromosome features, chromosome
radial position and chromosome relative position. This methodology allows the unequivocally identification and the
analysis of the chromosome territories of all spermatogenic stages. Results will provide information about the features
that determine chromosomal position, preferred associations between chromosomes, and the relationship between chromosome
positioning and genome regulation.
|
|
Mireia Sole, Joan Blanco, Debora Gil, G. Fonseka, Richard Frodsham, Oliver Valero, et al. (2017). Is there a pattern of Chromosome territoriality along mice spermatogenesis? In 3rd Spanish MeioNet Meeting Abstract Book (pp. 55–56).
|
|
Mireia Sole, Joan Blanco, Debora Gil, G. Fonseka, Richard Frodsham, Oliver Valero, et al. (2017). Unraveling the enigmas of chromosome territoriality during spermatogenesis. In IX Jornada del Departament de Biologia Cel•lular, Fisiologia i Immunologia.
|
|
Mireia Sole, Joan Blanco, Debora Gil, G. Fonseka, Richard Frodsham, Oliver Valero, et al. (2017). Análisis 3d de la territorialidad cromosómica en células espermatogénicas: explorando la infertilidad desde un nuevo prisma. ASEBIR - Revista Asociación para el Estudio de la Biología de la Reproducción, 105.
|
Mireia Sole, Joan Blanco, Debora Gil, Oliver Valero, Alvaro Pascual, B. Cardenas, et al. (2021). Chromosomal positioning in spermatogenic cells is influenced by chromosomal factors associated with gene activity, bouquet formation, and meiotic sex-chromosome inactivation. Chromosoma, 130, 163–175.
Abstract: Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation.
|
