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	Author	Frederic Sampedro; Anna Domenech; Sergio Escalera
	Title	Static and dynamic computational cancer spread quantification in whole body FDG-PET/CT scans			Type	Journal Article
	Year	2014	Publication	Journal of Medical Imaging and Health Informatics	Abbreviated Journal	JMIHI
	Volume	4	Issue	6	Pages	825-831
	Keywords	CANCER SPREAD; COMPUTER AIDED DIAGNOSIS; MEDICAL IMAGING; TUMOR QUANTIFICATION
	Abstract	In this work we address the computational cancer spread quantification scenario in whole body FDG-PET/CT scans. At the static level, this setting can be modeled as a clustering problem on the set of 3D connected components of the whole body PET tumoral segmentation mask carried out by nuclear medicine physicians. At the dynamic level, and ad-hoc algorithm is proposed in order to quantify the cancer spread time evolution which, when combined with other existing indicators, gives rise to the metabolic tumor volume-aggressiveness-spread time evolution chart, a novel tool that we claim that would prove useful in nuclear medicine and oncological clinical or research scenarios. Good performance results of the proposed methodologies both at the clinical and technological level are shown using a dataset of 48 segmented whole body FDG-PET/CT scans.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	HuPBA;MILAB			Approved	no
	Call Number	Admin @ si @ SDE2014b			Serial	2548
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	Author	Frederic Sampedro; Anna Domenech; Sergio Escalera
	Title	Obtaining quantitative global tumoral state indicators based on whole-body PET/CT scans: A breast cancer case study			Type	Journal Article
	Year	2014	Publication	Nuclear Medicine Communications	Abbreviated Journal	NMC
	Volume	35	Issue	4	Pages	362-371
	Keywords
	Abstract	Objectives: In this work we address the need for the computation of quantitative global tumoral state indicators from oncological whole-body PET/computed tomography scans. The combination of such indicators with other oncological information such as tumor markers or biopsy results would prove useful in oncological decision-making scenarios. Materials and methods: From an ordering of 100 breast cancer patients on the basis of oncological state through visual analysis by a consensus of nuclear medicine specialists, a set of numerical indicators computed from image analysis of the PET/computed tomography scan is presented, which attempts to summarize a patient’s oncological state in a quantitative manner taking into consideration the total tumor volume, aggressiveness, and spread. Results: Results obtained by comparative analysis of the proposed indicators with respect to the experts’ evaluation show up to 87% Pearson’s correlation coefficient when providing expert-guided PET metabolic tumor volume segmentation and 64% correlation when using completely automatic image analysis techniques. Conclusion: Global quantitative tumor information obtained by whole-body PET/CT image analysis can prove useful in clinical nuclear medicine settings and oncological decision-making scenarios. The completely automatic computation of such indicators would improve its impact as time efficiency and specialist independence would be achieved.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	HuPBA;MILAB			Approved	no
	Call Number	SDE2014a			Serial	2444
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