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| Author |
Jaume Garcia; Debora Gil; A.Bajo; M.J.Ledesma-Carbayo; C.SantaMarta |
| Title |
Influence of the temporal resolution on the quantification of displacement fields in cardiac magnetic resonance tagged images |
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Conference Article |
| Year |
2008 |
Publication |
Proc. Computers in Cardiology |
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| Volume |
35 |
Issue |
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Pages |
785-788 |
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| Abstract |
It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possible. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%. |
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Alan Murray |
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IAM @ iam @ GGB2008 |
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1508 |
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| Author |
Jaume Garcia; Debora Gil; Joel Barajas; Francesc Carreras; Sandra Pujades; Petia Radeva |
| Title |
Characterization of ventricular torsion in healthy subjects using Gabor filters and a variational framework |
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Conference Article |
| Year |
2006 |
Publication |
Proc. Computers in Cardiology |
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Pages |
877-880 |
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In this work, we present a fully automated method for tissue deformation estimation in tagged magnetic resonance images (TMRI). Gabor filter banks, tuned independently for each left ventricle level, provide optimally filtered complex images which phase remains constant along the cardiac cycle. This fact can be thought as the brightness constancy condition required by classical optical flow (OF) methods. Pairs of these filtered sequences, together with a variational formulation are used in a second step to obtain dense continuous deformation maps that we call Harmonic Phase Flow. This method has been used to determine reference values of ventricular torsion (VT) in a set of 8 healthy volunteers. The results encourage the use of VT as a useful parameter for ventricular function assessment in clinical routine. |
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IAM;MILAB |
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IAM @ iam @ GGB2006a |
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1509 |
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| Author |
Jaume Garcia; Francesc Carreras; Sandra Pujades; Debora Gil |
| Title |
Regional motion patterns for the Left Ventricle function assessment |
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Conference Article |
| Year |
2008 |
Publication |
Proc. 19th Int. Conf. Pattern Recognition ICPR 2008 |
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1-4 |
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Regional scores (e.g. strain, perfusion) of the Left Ventricle (LV) functionality are playing an increasing role in the diagnosis of cardiac diseases. A main limitation is the lack of normality models for complementary scores oriented to assessment of the LV integrity. This paper introduces an original framework based on a parametrization of the LV domain, which allows comparison across subjects of local physiological measures of different nature. We compute regional normality patterns in a feature space characterizing the LV function. We show the consistency of the model for the regional motion on healthy and hypokinetic pathological cases |
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IAM @ iam @ GCP2008 |
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1510 |
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| Author |
Jaume Garcia; David Rotger; Francesc Carreras; R.Leta; Petia Radeva |
| Title |
Contrast echography segmentation and tracking by trained deformable models |
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Conference Article |
| Year |
2003 |
Publication |
Proc. Computers in Cardiology |
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| Volume |
30 |
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173-176 |
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The objective of this work is to segment the human left ventricle myocardium (LVM) in contrast echocardiography imaging and thus track it along a cardiac cycle in order to extract quantitative data about heart function. Ultrasound images are hard to work with due to their speckle appearance. To overcome this we report the combination of active contour models (ACM) or snakes and active shape models (ASM). The ability of ACM in giving closed and smooth curves in addition to the power of the ASM in producing shapes similar to the ones learned, evoke to a robust algorithm. Meanwhile the snake is attracted towards image main features, ASM acts as a correction factor. The algorithm was tested independently on 180 frames and satisfying results were obtained: in 95% the maximum difference between automatic and experts segmentation was less than 12 pixels. |
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Centre de Visió per Computador – Dept. Informàtica, UAB Edifici O – Campus UAB, 08193 Bellater |
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0276-6547 |
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0-7803-8170-X |
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IAM;MILAB |
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IAM @ iam @ GRC2003 |
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1512 |
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| Author |
M. Gomez; J. Mauri; Eduard Fernandez-Nofrerias; Oriol Rodriguez-Leor; Carme Julia; Debora Gil; Petia Radeva |
| Title |
Reconstrucción de un modelo espacio-temporal de la luz del vaso a partir de secuencias de ecografía intracoronaria |
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Conference Article |
| Year |
2002 |
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XXXVIII Congreso Nacional de la Sociedad Española de Cardiología. |
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IAM;ADAS;MILAB |
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IAM @ iam @ GMF2002d |
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1516 |
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| Author |
Debora Gil; Jaume Garcia; Ruth Aris; Guillaume Houzeaux; Manuel Vazquez |
| Title |
A Riemmanian approach to cardiac fiber architecture modelling |
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Conference Article |
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2009 |
Publication |
1st International Conference on Mathematical & Computational Biomedical Engineering |
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59-62 |
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cardiac fiber architecture; diffusion tensor magnetic resonance imaging; differential (Rie- mannian) geometry. |
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There is general consensus that myocardial fiber architecture should be modelled in order to fully understand the electromechanical properties of the Left Ventricle (LV). Diffusion Tensor magnetic resonance Imaging (DTI) is the reference image modality for rapid measurement of fiber orientations by means of the tensor principal eigenvectors. In this work, we present a mathematical framework for across subject comparison of the local geometry of the LV anatomy including the fiber architecture from the statistical analysis of DTI studies. We use concepts of differential geometry for defining a parametric domain suitable for statistical analysis of a low number of samples. We use Riemannian metrics to define a consistent computation of DTI principal eigenvector modes of variation. Our framework has been applied to build an atlas of the LV fiber architecture from 7 DTI normal canine hearts. |
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Swansea (UK) |
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Nithiarasu, R.L.R.V.L. |
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CMBE |
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IAM |
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IAM @ iam @ FGA2009 |
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1520 |
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| Author |
Debora Gil; Jaume Garcia; Manuel Vazquez; Ruth Aris; Guillaume Houzeaux |
| Title |
Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function |
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Conference Article |
| Year |
2008 |
Publication |
8th World Congress on Computational Mechanichs (WCCM8)/5th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2008) |
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Left Ventricle; Electromechanical Models; Image Processing; Magnetic Resonance. |
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Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality . In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp. We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment. The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted. The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model. |
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Venezia (Italia) |
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B-31470-08 |
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IAM |
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no |
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IAM @ iam @ GGV2008c |
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1521 |
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| Author |
Debora Gil; Jaume Garcia; Aura Hernandez-Sabate; Enric Marti |
| Title |
Manifold parametrization of the left ventricle for a statistical modelling of its complete anatomy |
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Conference Article |
| Year |
2010 |
Publication |
8th Medical Imaging |
Abbreviated Journal |
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| Volume |
7623 |
Issue |
762304 |
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304 |
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Distortion of Left Ventricle (LV) external anatomy is related to some dysfunctions, such as hypertrophy. The architecture of myocardial fibers determines LV electromechanical activation patterns as well as mechanics. Thus, their joined modelling would allow the design of specific interventions (such as peacemaker implantation and LV remodelling) and therapies (such as resynchronization). On one hand, accurate modelling of external anatomy requires either a dense sampling or a continuous infinite dimensional approach, which requires non-Euclidean statistics. On the other hand, computation of fiber models requires statistics on Riemannian spaces. Most approaches compute separate statistical models for external anatomy and fibers architecture. In this work we propose a general mathematical framework based on differential geometry concepts for computing a statistical model including, both, external and fiber anatomy. Our framework provides a continuous approach to external anatomy supporting standard statistics. We also provide a straightforward formula for the computation of the Riemannian fiber statistics. We have applied our methodology to the computation of complete anatomical atlas of canine hearts from diffusion tensor studies. The orientation of fibers over the average external geometry agrees with the segmental description of orientations reported in the literature. |
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SPIE |
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SPIE |
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IAM |
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IAM @ iam @ GGH2010a |
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1522 |
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Debora Gil; Oriol Rodriguez; J. Mauri; Petia Radeva |
| Title |
Statistical descriptors of the Myocardial perfusion in angiographic images |
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Conference Article |
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2006 |
Publication |
Proc. Computers in Cardiology |
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Pages |
677-680 |
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Anisotropic processing; intravascular ultrasound (IVUS); vessel border segmentation; vessel structure classification. |
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Restoration of coronary flow after primary percutaneous coronary intervention in acute myocardial infarction does not always correlate with adequate myocardial perfusion. Recently, coronary angiography has been used to assess microcirculation integrity (Myocardial BlushAnalysis, MBA). Although MBA correlates with patient prognosis there are few image processing methods addressing objective perfusion quantification. The goal of this work is to develop statistical descriptors of the myocardial dyeing pattern allowing objective assessment of myocardial perfusion. Experiments on healthy right coronary arteries show that our approach allows reliable measurements without any specific image acquisition protocol. |
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IAM;MILAB |
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IAM @ iam @ GRR2006 |
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1528 |
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Debora Gil; Petia Radeva; J. Mauri |
| Title |
Ivus Segmentation Via a Regularized Curvature Flow |
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Conference Article |
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2002 |
Publication |
X Congreso Anual de la Sociedad Española de Ingeniería Biomédica CASEIB 2002 |
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133-136 |
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Cardiac diseases are diagnosed and treated through a study of the morphology and dynamics of cardiac arteries. In- travascular Ultrasound (IVUS) imaging is of high interest to physicians since it provides both information. At the current state-of-the-art in image segmentation, a robust detection of the arterial lumen in IVUS demands manual intervention or ECG-gating. Manual intervention is a tedious and time consuming task that requires experienced observers, meanwhile ECG-gating is an acquisition technique not available in all clinical centers. We introduce a parametric algorithm that detects the arterial luminal border in in vivo sequences. The method consist in smoothing the sequences’ level surfaces under a regularized mean curvature flow that admits non-trivial steady states. The flow is based on a measure of the surface local smoothness that takes into account regularity of the surface curvature. |
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Saragossa, Espanya |
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IAM;MILAB |
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IAM @ iam @ GRM2002 |
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1536 |
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Debora Gil; Petia Radeva; Jordi Saludes; J. Mauri |
| Title |
Automatic Segmentation of Artery Wall in Coronary IVUS Images: A Probabilistic Approach |
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Conference Article |
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2000 |
Publication |
International Conference on Pattern Recognition |
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4 |
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352-355 |
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Intravascular ultrasound images represent a unique tool to analyze the morphology of arteries and vessels (plaques, restenosis, etc). The poor quality of these images makes unsupervised segmentation based on traditional segmentation algorithms (such as edge or ridge/valley detection) fail to achieve the expected results. In this paper we present a probabilistic flexible template to separate different regions in the image. In particular, we use elliptic templates to model and detect the shape of the vessel inner wall in IVUS images. We present the results of successful segmentation obtained from patients undergoing stent treatment. A physician team has validated these results. |
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IAM;MILAB |
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IAM @ iam @ GRS2000a |
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1537 |
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Debora Gil; Petia Radeva; Jordi Saludes; J. Mauri |
| Title |
Automatic Segmentation of Artery Wall in Coronary IVUS Images: a Probabilistic Approach |
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Conference Article |
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2000 |
Publication |
Proceedings of CIC’2000 |
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Intravascular ultrasound images represent a unique tool to analyze the morphology of arteries and vessels (plaques, restenosis, etc). The poor quality of these images makes unsupervised segmentation based on traditional segmentation algorithms (such as edge or ridge/valley detection) fail to achieve the expected results. In this paper we present a probabilistic flexible template to separate different regions in the image. In particular, we use elliptic templates to model and detect the shape of the vessel inner wall in IVUS images. We present the results of successful segmentation obtained from patients undergoing stent treatment. A physician team has validated these results. |
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Cambridge, Massachussets |
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CIC |
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IAM;MILAB |
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IAM @ iam @ GRS2000 |
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1538 |
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Aura Hernandez-Sabate; Debora Gil; Petia Radeva |
| Title |
On the usefulness of supervised learning for vessel border detection in IntraVascular Imaging |
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Conference Article |
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2005 |
Publication |
Proceeding of the 2005 conference on Artificial Intelligence Research and Development |
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67-74 |
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classification; vessel border modelling; IVUS |
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IntraVascular UltraSound (IVUS) imaging is a useful tool in diagnosis of cardiac diseases since sequences completely show the morphology of coronary vessels. Vessel borders detection, especially the external adventitia layer, plays a central role in morphological measures and, thus, their segmentation feeds development of medical imaging techniques. Deterministic approaches fail to yield optimal results due to the large amount of IVUS artifacts and vessel borders descriptors. We propose using classification techniques to learn the set of descriptors and parameters that best detect vessel borders. Statistical hypothesis test on the error between automated detections and manually traced borders by 4 experts show that our detections keep within inter-observer variability. |
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IOS Press |
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Amsterdam, The Netherlands |
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IAM;MILAB |
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IAM @ iam @ HGR2005c |
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1549 |
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| Author |
Aura Hernandez-Sabate; Debora Gil; Albert Teis |
| Title |
How Do Conservation Laws Define a Motion Suppression Score in In-Vivo Ivus Sequences? |
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Conference Article |
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2007 |
Publication |
Proc. IEEE Ultrasonics Symp |
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2231-2234 |
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validation standards; IVUS motion compensation; conservation laws. |
| Abstract |
Evaluation of arterial tissue biomechanics for diagnosis and treatment of cardiovascular diseases is an active research field in the biomedical imaging processing area. IntraVascular UltraSound (IVUS) is a unique tool for such assessment since it reflects tissue morphology and deformation. A proper quantification and visualization of both properties is hindered by vessel structures misalignments introduced by cardiac dynamics. This has encouraged development of IVUS motion compensation techniques. However, there is a lack of an objective evaluation of motion reduction ensuring a reliable clinical application This work reports a novel score, the Conservation of Density Rate (CDR), for validation of motion compensation in in-vivo pullbacks. Synthetic experiments validate the proposed score as measure of motion parameters accuracy; while results in in vivo pullbacks show its reliability in clinical cases. |
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IAM |
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no |
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IAM @ iam @ HTG2007 |
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1550 |
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| Author |
Aura Hernandez-Sabate; Monica Mitiko; Sergio Shiguemi; Debora Gil |
| Title |
A validation protocol for assessing cardiac phase retrieval in IntraVascular UltraSound |
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Conference Article |
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2010 |
Publication |
Computing in Cardiology |
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37 |
Issue |
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899-902 |
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| Abstract |
A good reliable approach to cardiac triggering is of utmost importance in obtaining accurate quantitative results of atherosclerotic plaque burden from the analysis of IntraVascular UltraSound. Although, in the last years, there has been an increase in research of methods for retrospective gating, there is no general consensus in a validation protocol. Many methods are based on quality assessment of longitudinal cuts appearance and those reporting quantitative numbers do not follow a standard protocol. Such heterogeneity in validation protocols makes faithful comparison across methods a difficult task. We propose a validation protocol based on the variability of the retrieved cardiac phase and explore the capability of several quality measures for quantifying such variability. An ideal detector, suitable for its application in clinical practice, should produce stable phases. That is, it should always sample the same cardiac cycle fraction. In this context, one should measure the variability (variance) of a candidate sampling with respect a ground truth (reference) sampling, since the variance would indicate how spread we are aiming a target. In order to quantify the deviation between the sampling and the ground truth, we have considered two quality scores reported in the literature: signed distance to the closest reference sample and distance to the right of each reference sample. We have also considered the residuals of the regression line of reference against candidate sampling. The performance of the measures has been explored on a set of synthetic samplings covering different cardiac cycle fractions and variabilities. From our simulations, we conclude that the metrics related to distances are sensitive to the shift considered while the residuals are robust against fraction and variabilities as far as one can establish a pair-wise correspondence between candidate and reference. We will further investigate the impact of false positive and negative detections in experimental data. |
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IEEE |
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0276-6547 |
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978-1-4244-7318-2 |
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CINC |
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IAM; |
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IAM @ iam @ HSM2010 |
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1551 |
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