Abstract: Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue.

Abstract: In the film industry, the same movie is expected to be watched on displays of vastly different sizes, from cinema screens to mobile phones. But visual induction, the perceptual phenomenon by which the appearance of a scene region is affected by its surroundings, will be different for the same image shown on two displays of different dimensions. This phenomenon presents a practical challenge for the preservation of the artistic intentions of filmmakers, because it can lead to shifts in image appearance between viewing destinations. In this work, we show that a neural field model based on the efficient representation principle is able to predict induction effects and how, by regularizing its associated energy functional, the model is still able to represent induction but is now invertible. From this finding, we propose a method to preprocess an image in a screen–size dependent way so that its perception, in terms of visual induction, may remain constant across displays of different size. The potential of the method is demonstrated through psychophysical experiments on synthetic images and qualitative examples on natural images.

Abstract: Handwritten Text Recognition has achieved an impressive performance in public benchmarks. However, due to the high inter- and intra-class variability between handwriting styles, such recognizers need to be trained using huge volumes of manually labeled training data. To alleviate this labor-consuming problem, synthetic data produced with TrueType fonts has been often used in the training loop to gain volume and augment the handwriting style variability. However, there is a significant style bias between synthetic and real data which hinders the improvement of recognition performance. To deal with such limitations, we propose a generative method for handwritten text-line images, which is conditioned on both visual appearance and textual content. Our method is able to produce long text-line samples with diverse handwriting styles. Once properly trained, our method can also be adapted to new target data by only accessing unlabeled text-line images to mimic handwritten styles and produce images with any textual content. Extensive experiments have been done on making use of the generated samples to boost Handwritten Text Recognition performance. Both qualitative and quantitative results demonstrate that the proposed approach outperforms the current state of the art.

Abstract: This paper presents a new model for the task of scene text visual question answering. In this task questions about a given image can only be answered by reading and understanding scene text. Current state of the art models for this task make use of a dual attention mechanism in which one attention module attends to visual features while the other attends to textual features. A possible issue with this is that it makes difficult for the model to reason jointly about both modalities. To fix this problem we propose a new model that is based on an single attention mechanism that attends to multi-modal features conditioned to the question. The output weights of this attention module over a grid of multi-modal spatial features are interpreted as the probability that a certain spatial location of the image contains the answer text to the given question. Our experiments demonstrate competitive performance in two standard datasets with a model that is faster than previous methods at inference time. Furthermore, we also provide a novel analysis of the ST-VQA dataset based on a human performance study. Supplementary material, code, and data is made available through this link.

Abstract: Current tasks and methods in Document Understanding aims to process documents as single elements. However, documents are usually organized in collections (historical records, purchase invoices), that provide context useful for their interpretation. To address this problem, we introduce Document Collection Visual Question Answering (DocCVQA) a new dataset and related task, where questions are posed over a whole collection of document images and the goal is not only to provide the answer to the given question, but also to retrieve the set of documents that contain the information needed to infer the answer. Along with the dataset we propose a new evaluation metric and baselines which provide further insights to the new dataset and task.

Abstract: This book contains the proceedings of the 16th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications (VISIGRAPP 2021) which was organized and sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC), endorsed by the International Association for Pattern Recognition (IAPR), and in cooperation with the ACM Special Interest Group on Graphics and Interactive Techniques (SIGGRAPH), the European Association for Computer Graphics (EUROGRAPHICS), the EUROGRAPHICS Portuguese Chapter, the VRVis Center for Virtual Reality and Visualization Forschungs-GmbH, the French Association for Computer Graphics (AFIG), and the Society for Imaging Science and Technology (IS&T). The proceedings here published demonstrate new and innovative solutions and highlight technical problems in each field that are challenging and worthy of being disseminated to the interested research audiences. VISIGRAPP 2021 was organized to promote a discussion forum about the conference’s research topics between researchers, developers, manufacturers and end-users, and to establish guidelines in the development of more advanced solutions. This year VISIGRAPP was, exceptionally, held as a web-based event, due to the COVID-19 pandemic, from 8 – 10 February. We received a high number of paper submissions for this edition of VISIGRAPP, 371 in total, with contributions from 52 countries. This attests to the success and global dimension of VISIGRAPP. To evaluate each submission, we used a hierarchical process of double-blind evaluation where each paper was reviewed by two to six experts from the International Program Committee (IPC). The IPC selected for oral presentation and for publication as full papers 12 papers from GRAPP, 8 from HUCAPP, 11 papers from IVAPP, and 56 papers from VISAPP, which led to a result for the full-paper acceptance ratio of 24% and a high-quality program. Apart from the above full papers, the conference program also features 118 short papers and 67 poster presentations. We hope that these conference proceedings, which are submitted for indexation by Thomson Reuters Conference Proceedings Citation Index, SCOPUS, DBLP, Semantic Scholar, Google Scholar, EI and Microsoft Academic, will help the Computer Vision, Imaging, Visualization, Computer Graphics and Human-Computer Interaction communities to find interesting research work. Moreover, we are proud to inform that the program also includes three plenary keynote lectures, given by internationally distinguished researchers, namely Federico Tombari (Google and Technical University of Munich, Germany), Dieter Schmalstieg (Graz University of Technology, Austria) and Nathalie Henry Riche (Microsoft Research, United States), thus contributing to increase the overall quality of the conference and to provide a deeper understanding of the conference’s interest fields. Furthermore, a short list of the presented papers will be selected to be extended into a forthcoming book of VISIGRAPP Selected Papers to be published by Springer during 2021 in the CCIS series. Moreover, a short list of presented papers will be selected for publication of extended and revised versions in a special issue of the Springer Nature Computer Science journal. All papers presented at this conference will be available at the SCITEPRESS Digital Library. Three awards are delivered at the closing session, to recognize the best conference paper, the best student paper and the best poster for each of the four conferences. There is also an award for best industrial paper to be delivered at the closing session for VISAPP. We would like to express our thanks, first of all, to the authors of the technical papers, whose work and dedication made it possible to put together a program that we believe to be very exciting and of high technical quality. Next, we would like to thank the Area Chairs, all the members of the program committee and auxiliary reviewers, who helped us with their expertise and time. We would also like to thank the invited speakers for their invaluable contribution and for sharing their vision in their talks. Finally, we gratefully acknowledge the professional support of the INSTICC team for all organizational processes, especially given the need to introduce online streaming, forum management, direct messaging facilitation and other web-based activities in order to make it possible for VISIGRAPP 2021 authors to present their work and share ideas with colleagues in spite of the logistic difficulties caused by the current pandemic situation. We wish you all an exciting conference. We hope to meet you again for the next edition of VISIGRAPP, details of which are available at http://www. visigrapp.org.

Abstract: Multi-modal medical image fusion plays an important role in clinical diagnosis and works as an assistance model for clinicians. In this paper, a computed tomography-magnetic resonance (CT-MR) image fusion model is proposed using an optimized bio-inspired spiking feedforward neural network in different decomposition domains. First, source images are decomposed into base (low-frequency) and detail (high-frequency) layer components. Low-frequency subbands are fused using texture energy measures to capture the local energy, contrast, and small edges in the fused image. High-frequency coefficients are fused using firing maps obtained by pixel-activated neural model with the optimized parameters using three different optimization techniques such as differential evolution, cuckoo search, and gray wolf optimization, individually. In the optimization model, a fitness function is computed based on the edge index of resultant fused images, which helps to extract and preserve sharp edges available in the source CT and MR images. To validate the fusion performance, a detailed comparative analysis is presented among the proposed and state-of-the-art methods in terms of quantitative and qualitative measures along with computational complexity. Experimental results show that the proposed method produces a significantly better visual quality of fused images meanwhile outperforms the existing methods.