Abstract: This book contains the proceedings of the 16th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications (VISIGRAPP 2021) which was organized and sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC), endorsed by the International Association for Pattern Recognition (IAPR), and in cooperation with the ACM Special Interest Group on Graphics and Interactive Techniques (SIGGRAPH), the European Association for Computer Graphics (EUROGRAPHICS), the EUROGRAPHICS Portuguese Chapter, the VRVis Center for Virtual Reality and Visualization Forschungs-GmbH, the French Association for Computer Graphics (AFIG), and the Society for Imaging Science and Technology (IS&T). The proceedings here published demonstrate new and innovative solutions and highlight technical problems in each field that are challenging and worthy of being disseminated to the interested research audiences. VISIGRAPP 2021 was organized to promote a discussion forum about the conference’s research topics between researchers, developers, manufacturers and end-users, and to establish guidelines in the development of more advanced solutions. This year VISIGRAPP was, exceptionally, held as a web-based event, due to the COVID-19 pandemic, from 8 – 10 February. We received a high number of paper submissions for this edition of VISIGRAPP, 371 in total, with contributions from 52 countries. This attests to the success and global dimension of VISIGRAPP. To evaluate each submission, we used a hierarchical process of double-blind evaluation where each paper was reviewed by two to six experts from the International Program Committee (IPC). The IPC selected for oral presentation and for publication as full papers 12 papers from GRAPP, 8 from HUCAPP, 11 papers from IVAPP, and 56 papers from VISAPP, which led to a result for the full-paper acceptance ratio of 24% and a high-quality program. Apart from the above full papers, the conference program also features 118 short papers and 67 poster presentations. We hope that these conference proceedings, which are submitted for indexation by Thomson Reuters Conference Proceedings Citation Index, SCOPUS, DBLP, Semantic Scholar, Google Scholar, EI and Microsoft Academic, will help the Computer Vision, Imaging, Visualization, Computer Graphics and Human-Computer Interaction communities to find interesting research work. Moreover, we are proud to inform that the program also includes three plenary keynote lectures, given by internationally distinguished researchers, namely Federico Tombari (Google and Technical University of Munich, Germany), Dieter Schmalstieg (Graz University of Technology, Austria) and Nathalie Henry Riche (Microsoft Research, United States), thus contributing to increase the overall quality of the conference and to provide a deeper understanding of the conference’s interest fields. Furthermore, a short list of the presented papers will be selected to be extended into a forthcoming book of VISIGRAPP Selected Papers to be published by Springer during 2021 in the CCIS series. Moreover, a short list of presented papers will be selected for publication of extended and revised versions in a special issue of the Springer Nature Computer Science journal. All papers presented at this conference will be available at the SCITEPRESS Digital Library. Three awards are delivered at the closing session, to recognize the best conference paper, the best student paper and the best poster for each of the four conferences. There is also an award for best industrial paper to be delivered at the closing session for VISAPP. We would like to express our thanks, first of all, to the authors of the technical papers, whose work and dedication made it possible to put together a program that we believe to be very exciting and of high technical quality. Next, we would like to thank the Area Chairs, all the members of the program committee and auxiliary reviewers, who helped us with their expertise and time. We would also like to thank the invited speakers for their invaluable contribution and for sharing their vision in their talks. Finally, we gratefully acknowledge the professional support of the INSTICC team for all organizational processes, especially given the need to introduce online streaming, forum management, direct messaging facilitation and other web-based activities in order to make it possible for VISIGRAPP 2021 authors to present their work and share ideas with colleagues in spite of the logistic difficulties caused by the current pandemic situation. We wish you all an exciting conference. We hope to meet you again for the next edition of VISIGRAPP, details of which are available at http://www. visigrapp.org.