Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.

Abstract: The original idea of this project was to study the role of colour in the challenging task of object recognition. We started by extending previous research on colour naming showing that it is feasible to capture colour terms through parsimonious ellipsoids. Although, the results of our model exceeded state-of-the-art in two benchmark datasets, we realised that the two phenomena of metameric lights and colour constancy must be addressed prior to any further colour processing. Our investigation of metameric pairs reached the conclusion that they are infrequent in real world scenarios. Contrary to that, the illumination of a scene often changes dramatically. We addressed this issue by proposing a colour constancy model inspired by the dynamical centre-surround adaptation of neurons in the visual cortex. This was implemented through two overlapping asymmetric Gaussians whose variances and heights are adjusted according to the local contrast of pixels. We complemented this model with a generic contrast-variant pooling mechanism that inversely connect the percentage of pooled signal to the local contrast of a region. The results of our experiments on four benchmark datasets were indeed promising: the proposed model, although simple, outperformed even learning-based approaches in many cases. Encouraged by the success of our contrast-variant surround modulation, we extended this approach to detect boundaries of objects. We proposed an edge detection model based on the first derivative of the Gaussian kernel. We incorporated four types of surround: full, far, iso- and orthogonal-orientation. Furthermore, we accounted for the pooling mechanism at higher cortical areas and the shape feedback sent to lower areas. Our results in three benchmark datasets showed significant improvement over non-learning algorithms.
To summarise, we demonstrated that biologically-inspired models offer promising solutions to computer vision problems, such as, colour naming, colour constancy and edge detection. We believe that the greatest contribution of this Ph.D dissertation is modelling the concept of dynamic surround modulation that shows the significance of contrast-variant surround integration. The models proposed here are grounded on only a portion of what we know about the human visual system. Therefore, it is only natural to complement them accordingly in future works.

Abstract: The pairwise classification approach tends to perform better than other well-known approaches when dealing with multiclass classification problems. In the pairwise approach, however, the nuisance votes of many irrelevant classifiers may result in a wrong prediction class. To overcome this problem, a novel method, Local Crossing Off (LCO), is presented and evaluated in this paper. The proposed LCO system takes advantage of nearest neighbor classification algorithm because of its simplicity and speed, as well as the strength of other two powerful binary classifiers to discriminate between two classes. This paper provides a set of experimental results on 20 datasets using two base learners: Neural Networks and Support Vector Machines. The results show that the proposed technique not only achieves better classification accuracy, but also is computationally more efficient for tackling classification problems which have a relatively large number of target classes.

Abstract: The perceived colour of a stimulus is dependent on multiple factors stemming out either from the context of the stimulus or idiosyncrasies of the observer. The complexity involved in combining these multiple effects is the main reason for the gap between classical calibrated colour spaces from colour science and colour representations used in computer vision, where colour is just one more visual cue immersed in a digital image where surfaces, shadows and illuminants interact seemingly out of control. With the aim to advance a few steps towards bridging this gap we present some results on computational representations of colour for computer vision. They have been developed by introducing perceptual considerations derived from the interaction of the colour of a point with its context. We show some techniques to represent the colour of a point influenced by assimilation and contrast effects due to the image surround and we show some results on how colour saliency can be derived in real images. We outline a model for automatic assignment of colour names to image points directly trained on psychophysical data. We show how colour segments can be perceptually grouped in the image by imposing shading coherence in the colour space.

Abstract: The performance of deep neural networks highly depends on the quality and volume of the training data. However, cost-effective labelling processes such as crowdsourcing and web crawling often lead to data with noisy (i.e., wrong) labels. Making models robust to this label noise is thus of prime importance. A common approach is using loss distributions to model the label noise. However, the robustness of these methods highly depends on the accuracy of the division of training set into clean and noisy samples. In this work, we dive in this research direction highlighting the existing problem of treating this distribution globally and propose a class-conditional approach to split the clean and noisy samples. We apply our approach to the popular DivideMix algorithm and show how the local treatment fares better with respect to the global treatment of loss distribution. We validate our hypothesis on two popular benchmark datasets and show substantial improvements over the baseline experiments. We further analyze the effectiveness of the proposal using two different metrics – Noise Division Accuracy and Classiness.

Abstract: The performance of different action-recognition methods using skeleton joint locations have been recently studied by several computer vision researchers. However, the potential improvement in classification through classifier fusion by ensemble-based methods has remained unattended. In this work, we evaluate the performance of an ensemble of five action learning techniques, each performing the recognition task from a different perspective. The underlying rationale of the fusion approach is that different learners employ varying structures of input descriptors/features to be trained. These varying structures cannot be attached and used by a single learner. In addition, combining the outputs of several learners can reduce the risk of an unfortunate selection of a poorly performing learner. This leads to having a more robust and general-applicable framework. Also, we propose two simple, yet effective, action description techniques. In order to improve the recognition performance, a powerful combination strategy is utilized based on the Dempster-Shafer theory, which can effectively make use of diversity of base learners trained on different sources of information. The recognition results of the individual classifiers are compared with those obtained from fusing the classifiers' output, showing advanced performance of the proposed methodology.

Abstract: The power requirements of video-oculography systems can be prohibitive for high-speed operation on portable devices. Recently, low-power alternatives such as photosensors have been evaluated, providing gaze estimates at high frequency with a trade-off in accuracy and robustness. Potentially, an approach combining slow/high-fidelity and fast/low-fidelity sensors should be able to exploit their complementarity to track fast eye motion accurately and robustly. To foster research on this topic, we introduce OpenSFEDS, a near-eye gaze estimation dataset containing approximately 2M synthetic camera-photosensor image pairs sampled at 500 Hz under varied appearance and camera position. We also formulate the task of sensor fusion for gaze estimation, proposing a deep learning framework consisting in appearance-based encoding and temporal eye-state dynamics. We evaluate several single- and multi-rate fusion baselines on OpenSFEDS, achieving 8.7% error decrease when tracking fast eye movements with a multi-rate approach vs. a gaze forecasting approach operating with a low-speed sensor alone.