Abstract: Accurate detection of in-vivo vulnerable plaque in coronary arteries is still an open problem. Recent studies show that it is highly related to tissue structure and composition. Intravascular Ultrasound (IVUS) is a powerful imaging technique that gives a detailed cross-sectional image of the vessel, allowing to explore arteries morphology. IVUS data validation is usually performed by comparing post-mortem (in-vitro) IVUS data and corresponding histological analysis of the tissue. The main drawback of this method is the few number of available case studies and validated data due to the complex procedure of histological analysis of the tissue. On the other hand, IVUS data from in-vivo cases is easy to obtain but it can not be histologically validated. In this work, we propose to enhance the in-vitro training data set by selectively including examples from in-vivo plaques. For this purpose, a Sequential Floating Forward Selection method is reformulated in the context of plaque characterization. The enhanced classifier performance is validated on in-vitro data set, yielding an overall accuracy of 91.59% in discriminating among fibrotic, lipidic and calcified plaques, while reducing the gap between in-vivo and in-vitro data analysis. Experimental results suggest that the obtained classifier could be properly applied on in-vivo plaque characterization and also demonstrate that the common hypothesis of assuming the difference between in-vivo and in-vitro as negligible is incorrect.

Abstract: Local image features are often used to efficiently represent image content. The limited number of types of features that a local feature extractor responds to might be insufficient to provide a robust image representation. To overcome this limitation, we propose a context-aware feature extraction formulated under an information theoretic framework. The algorithm does not respond to a specific type of features; the idea is to retrieve complementary features which are relevant within the image context. We empirically validate the method by investigating the repeatability, the completeness, and the complementarity of context-aware features on standard benchmarks. In a comparison with strictly local features, we show that our context-aware features produce more robust image representations. Furthermore, we study the complementarity between strictly local features and context-aware ones to produce an even more robust representation.