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Laura Igual, Joan Carles Soliva, Antonio Hernandez, Sergio Escalera, Xavier Jimenez, Oscar Vilarroya, et al. (2011). A fully-automatic caudate nucleus segmentation of brain MRI: Application in volumetric analysis of pediatric attention-deficit/hyperactivity disorder. BEO - BioMedical Engineering Online, 10(105), 1–23.
Abstract: Background
Accurate automatic segmentation of the caudate nucleus in magnetic resonance images (MRI) of the brain is of great interest in the analysis of developmental disorders. Segmentation methods based on a single atlas or on multiple atlases have been shown to suitably localize caudate structure. However, the atlas prior information may not represent the structure of interest correctly. It may therefore be useful to introduce a more flexible technique for accurate segmentations.
Method
We present Cau-dateCut: a new fully-automatic method of segmenting the caudate nucleus in MRI. CaudateCut combines an atlas-based segmentation strategy with the Graph Cut energy-minimization framework. We adapt the Graph Cut model to make it suitable for segmenting small, low-contrast structures, such as the caudate nucleus, by defining new energy function data and boundary potentials. In particular, we exploit information concerning the intensity and geometry, and we add supervised energies based on contextual brain structures. Furthermore, we reinforce boundary detection using a new multi-scale edgeness measure.
Results
We apply the novel CaudateCut method to the segmentation of the caudate nucleus to a new set of 39 pediatric attention-deficit/hyperactivity disorder (ADHD) patients and 40 control children, as well as to a public database of 18 subjects. We evaluate the quality of the segmentation using several volumetric and voxel by voxel measures. Our results show improved performance in terms of segmentation compared to state-of-the-art approaches, obtaining a mean overlap of 80.75%. Moreover, we present a quantitative volumetric analysis of caudate abnormalities in pediatric ADHD, the results of which show strong correlation with expert manual analysis.
Conclusion
CaudateCut generates segmentation results that are comparable to gold-standard segmentations and which are reliable in the analysis of differentiating neuroanatomical abnormalities between healthy controls and pediatric ADHD.
Keywords: Brain caudate nucleus; segmentation; MRI; atlas-based strategy; Graph Cut framework
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Frederic Sampedro, Sergio Escalera, Anna Domenech, & Ignasi Carrio. (2015). Automatic Tumor Volume Segmentation in Whole-Body PET/CT Scans: A Supervised Learning Approach Source. JMIHI - Journal of Medical Imaging and Health Informatics, 5(2), 192–201.
Abstract: Whole-body 3D PET/CT tumoral volume segmentation provides relevant diagnostic and prognostic information in clinical oncology and nuclear medicine. Carrying out this procedure manually by a medical expert is time consuming and suffers from inter- and intra-observer variabilities. In this paper, a completely automatic approach to this task is presented. First, the problem is stated and described both in clinical and technological terms. Then, a novel supervised learning segmentation framework is introduced. The segmentation by learning approach is defined within a Cascade of Adaboost classifiers and a 3D contextual proposal of Multiscale Stacked Sequential Learning. Segmentation accuracy results on 200 Breast Cancer whole body PET/CT volumes show mean 49% sensitivity, 99.993% specificity and 39% Jaccard overlap Index, which represent good performance results both at the clinical and technological level.
Keywords: CONTEXTUAL CLASSIFICATION; PET/CT; SUPERVISED LEARNING; TUMOR SEGMENTATION; WHOLE BODY
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Sergio Escalera, Oriol Pujol, Petia Radeva, Jordi Vitria, & Maria Teresa Anguera. (2010). Automatic Detection of Dominance and Expected Interest. EURASIPJ - EURASIP Journal on Advances in Signal Processing, , 12.
Abstract: Article ID 491819
Social Signal Processing is an emergent area of research that focuses on the analysis of social constructs. Dominance and interest are two of these social constructs. Dominance refers to the level of influence a person has in a conversation. Interest, when referred in terms of group interactions, can be defined as the degree of engagement that the members of a group collectively display during their interaction. In this paper, we argue that only using behavioral motion information, we are able to predict the interest of observers when looking at face-to-face interactions as well as the dominant people. First, we propose a simple set of movement-based features from body, face, and mouth activity in order to define a higher set of interaction indicators. The considered indicators are manually annotated by observers. Based on the opinions obtained, we define an automatic binary dominance detection problem and a multiclass interest quantification problem. Error-Correcting Output Codes framework is used to learn to rank the perceived observer's interest in face-to-face interactions meanwhile Adaboost is used to solve the dominant detection problem. The automatic system shows good correlation between the automatic categorization results and the manual ranking made by the observers in both dominance and interest detection problems.
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Oriol Pujol, & Petia Radeva. (2004). Texture Segmentation by Statistical Deformable Models. IJIG - International Journal of Image and Graphics, 433–452.
Abstract: Deformable models have received much popularity due to their ability to include high-level knowledge on the application domain into low-level image processing. Still, most proposed active contour models do not sufficiently profit from the application information and they are too generalized, leading to non-optimal final results of segmentation, tracking or 3D reconstruction processes. In this paper we propose a new deformable model defined in a statistical framework to segment objects of natural scenes. We perform a supervised learning of local appearance of the textured objects and construct a feature space using a set of co-occurrence matrix measures. Linear Discriminant Analysis allows us to obtain an optimal reduced feature space where a mixture model is applied to construct a likelihood map. Instead of using a heuristic potential field, our active model is deformed on a regularized version of the likelihood map in order to segment objects characterized by the same texture pattern. Different tests on synthetic images, natural scene and medical images show the advantages of our statistic deformable model.
Keywords: Texture segmentation, parametric active contours, statistic snakes
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Sergio Escalera, Ana Puig, Oscar Amoros, & Maria Salamo. (2011). Intelligent GPGPU Classification in Volume Visualization: a framework based on Error-Correcting Output Codes. CGF - Computer Graphics Forum, 30(7), 2107–2115.
Abstract: IF JCR 1.455 2010 25/99
In volume visualization, the definition of the regions of interest is inherently an iterative trial-and-error process finding out the best parameters to classify and render the final image. Generally, the user requires a lot of expertise to analyze and edit these parameters through multi-dimensional transfer functions. In this paper, we present a framework of intelligent methods to label on-demand multiple regions of interest. These methods can be split into a two-level GPU-based labelling algorithm that computes in time of rendering a set of labelled structures using the Machine Learning Error-Correcting Output Codes (ECOC) framework. In a pre-processing step, ECOC trains a set of Adaboost binary classifiers from a reduced pre-labelled data set. Then, at the testing stage, each classifier is independently applied on the features of a set of unlabelled samples and combined to perform multi-class labelling. We also propose an alternative representation of these classifiers that allows to highly parallelize the testing stage. To exploit that parallelism we implemented the testing stage in GPU-OpenCL. The empirical results on different data sets for several volume structures shows high computational performance and classification accuracy.
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