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Frederic Sampedro, Anna Domenech, & Sergio Escalera. (2014). Obtaining quantitative global tumoral state indicators based on whole-body PET/CT scans: A breast cancer case study. NMC - Nuclear Medicine Communications, 35(4), 362–371.
Abstract: Objectives: In this work we address the need for the computation of quantitative global tumoral state indicators from oncological whole-body PET/computed tomography scans. The combination of such indicators with other oncological information such as tumor markers or biopsy results would prove useful in oncological decision-making scenarios.
Materials and methods: From an ordering of 100 breast cancer patients on the basis of oncological state through visual analysis by a consensus of nuclear medicine specialists, a set of numerical indicators computed from image analysis of the PET/computed tomography scan is presented, which attempts to summarize a patient’s oncological state in a quantitative manner taking into consideration the total tumor volume, aggressiveness, and spread.
Results: Results obtained by comparative analysis of the proposed indicators with respect to the experts’ evaluation show up to 87% Pearson’s correlation coefficient when providing expert-guided PET metabolic tumor volume segmentation and 64% correlation when using completely automatic image analysis techniques.
Conclusion: Global quantitative tumor information obtained by whole-body PET/CT image analysis can prove useful in clinical nuclear medicine settings and oncological decision-making scenarios. The completely automatic computation of such indicators would improve its impact as time efficiency and specialist independence would be achieved.
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Manisha Das, Deep Gupta, Petia Radeva, & Ashwini M. Bakde. (2021). Multi-scale decomposition-based CT-MR neurological image fusion using optimized bio-inspired spiking neural model with meta-heuristic optimization. IMA - International Journal of Imaging Systems and Technology, 31(4), 2170–2188.
Abstract: Multi-modal medical image fusion plays an important role in clinical diagnosis and works as an assistance model for clinicians. In this paper, a computed tomography-magnetic resonance (CT-MR) image fusion model is proposed using an optimized bio-inspired spiking feedforward neural network in different decomposition domains. First, source images are decomposed into base (low-frequency) and detail (high-frequency) layer components. Low-frequency subbands are fused using texture energy measures to capture the local energy, contrast, and small edges in the fused image. High-frequency coefficients are fused using firing maps obtained by pixel-activated neural model with the optimized parameters using three different optimization techniques such as differential evolution, cuckoo search, and gray wolf optimization, individually. In the optimization model, a fitness function is computed based on the edge index of resultant fused images, which helps to extract and preserve sharp edges available in the source CT and MR images. To validate the fusion performance, a detailed comparative analysis is presented among the proposed and state-of-the-art methods in terms of quantitative and qualitative measures along with computational complexity. Experimental results show that the proposed method produces a significantly better visual quality of fused images meanwhile outperforms the existing methods.
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Simone Balocco, Francesco Ciompi, Juan Rigla, Xavier Carrillo, J. Mauri, & Petia Radeva. (2019). Assessment of intracoronary stent location and extension in intravascular ultrasound sequences. MEDPHYS - Medical Physics, 46(2), 484–493.
Abstract: PURPOSE:
An intraluminal coronary stent is a metal scaffold deployed in a stenotic artery during percutaneous coronary intervention (PCI). In order to have an effective deployment, a stent should be optimally placed with regard to anatomical structures such as bifurcations and stenoses. Intravascular ultrasound (IVUS) is a catheter-based imaging technique generally used for PCI guiding and assessing the correct placement of the stent. A novel approach that automatically detects the boundaries and the position of the stent along the IVUS pullback is presented. Such a technique aims at optimizing the stent deployment.
METHODS:
The method requires the identification of the stable frames of the sequence and the reliable detection of stent struts. Using these data, a measure of likelihood for a frame to contain a stent is computed. Then, a robust binary representation of the presence of the stent in the pullback is obtained applying an iterative and multiscale quantization of the signal to symbols using the Symbolic Aggregate approXimation algorithm.
RESULTS:
The technique was extensively validated on a set of 103 IVUS of sequences of in vivo coronary arteries containing metallic and bioabsorbable stents acquired through an international multicentric collaboration across five clinical centers. The method was able to detect the stent position with an overall F-measure of 86.4%, a Jaccard index score of 75% and a mean distance of 2.5 mm from manually annotated stent boundaries, and in bioabsorbable stents with an overall F-measure of 88.6%, a Jaccard score of 77.7 and a mean distance of 1.5 mm from manually annotated stent boundaries. Additionally, a map indicating the distance between the lumen and the stent along the pullback is created in order to show the angular sectors of the sequence in which the malapposition is present.
CONCLUSIONS:
Results obtained comparing the automatic results vs the manual annotation of two observers shows that the method approaches the interobserver variability. Similar performances are obtained on both metallic and bioabsorbable stents, showing the flexibility and robustness of the method.
Keywords: IVUS; malapposition; stent; ultrasound
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Giuseppe Pezzano, Vicent Ribas Ripoll, & Petia Radeva. (2021). CoLe-CNN: Context-learning convolutional neural network with adaptive loss function for lung nodule segmentation. CMPB - Computer Methods and Programs in Biomedicine, 198, 105792.
Abstract: Background and objective:An accurate segmentation of lung nodules in computed tomography images is a crucial step for the physical characterization of the tumour. Being often completely manually accomplished, nodule segmentation turns to be a tedious and time-consuming procedure and this represents a high obstacle in clinical practice. In this paper, we propose a novel Convolutional Neural Network for nodule segmentation that combines a light and efficient architecture with innovative loss function and segmentation strategy. Methods:In contrast to most of the standard end-to-end architectures for nodule segmentation, our network learns the context of the nodules by producing two masks representing all the background and secondary-important elements in the Computed Tomography scan. The nodule is detected by subtracting the context from the original scan image. Additionally, we introduce an asymmetric loss function that automatically compensates for potential errors in the nodule annotations. We trained and tested our Neural Network on the public LIDC-IDRI database, compared it with the state of the art and run a pseudo-Turing test between four radiologists and the network. Results:The results proved that the behaviour of the algorithm is very near to the human performance and its segmentation masks are almost indistinguishable from the ones made by the radiologists. Our method clearly outperforms the state of the art on CT nodule segmentation in terms of F1 score and IoU of and respectively. Conclusions: The main structure of the network ensures all the properties of the UNet architecture, while the Multi Convolutional Layers give a more accurate pattern recognition. The newly adopted solutions also increase the details on the border of the nodule, even under the noisiest conditions. This method can be applied now for single CT slice nodule segmentation and it represents a starting point for the future development of a fully automatic 3D segmentation software.
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Santiago Segui, Michal Drozdzal, Guillem Pascual, Petia Radeva, Carolina Malagelada, Fernando Azpiroz, et al. (2016). Generic Feature Learning for Wireless Capsule Endoscopy Analysis. CBM - Computers in Biology and Medicine, 79, 163–172.
Abstract: The interpretation and analysis of wireless capsule endoscopy (WCE) recordings is a complex task which requires sophisticated computer aided decision (CAD) systems to help physicians with video screening and, finally, with the diagnosis. Most CAD systems used in capsule endoscopy share a common system design, but use very different image and video representations. As a result, each time a new clinical application of WCE appears, a new CAD system has to be designed from the scratch. This makes the design of new CAD systems very time consuming. Therefore, in this paper we introduce a system for small intestine motility characterization, based on Deep Convolutional Neural Networks, which circumvents the laborious step of designing specific features for individual motility events. Experimental results show the superiority of the learned features over alternative classifiers constructed using state-of-the-art handcrafted features. In particular, it reaches a mean classification accuracy of 96% for six intestinal motility events, outperforming the other classifiers by a large margin (a 14% relative performance increase).
Keywords: Wireless capsule endoscopy; Deep learning; Feature learning; Motility analysis
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