Abstract: Purpose of review
Atherosclerosis is the leading cause of cardiovascular disease (CVD) and stroke. Typically, atherosclerotic calcium is found during the mature stage of the atherosclerosis disease. It is therefore often a challenge to identify and quantify the calcium. This is due to the presence of multiple components of plaque buildup in the arterial walls. The American College of Cardiology/American Heart Association guidelines point to the importance of calcium in the coronary and carotid arteries and further recommend its quantification for the prevention of heart disease. It is therefore essential to stratify the CVD risk of the patient into low- and high-risk bins.
Recent finding
Calcium formation in the artery walls is multifocal in nature with sizes at the micrometer level. Thus, its detection requires high-resolution imaging. Clinical experience has shown that even though optical coherence tomography offers better resolution, intravascular ultrasound still remains an important imaging modality for coronary wall imaging. For a computer-based analysis system to be complete, it must be scientifically and clinically validated. This study presents a state-of-the-art review (condensation of 152 publications after examining 200 articles) covering the methods for calcium detection and its quantification for coronary and carotid arteries, the pros and cons of these methods, and the risk stratification strategies. The review also presents different kinds of statistical models and gold standard solutions for the evaluation of software systems useful for calcium detection and quantification. Finally, the review concludes with a possible vision for designing the next-generation system for better clinical outcomes.

Abstract: Many symbol recognition problems require the use of robust descriptors in order to obtain rich information of the data. However, the research of a good descriptor is still an open issue due to the high variability of symbols appearance. Rotation, partial occlusions, elastic deformations, intra-class and inter-class variations, or high variability among symbols due to different writing styles, are just a few problems. In this paper, we introduce a symbol shape description to deal with the changes in appearance that these types of symbols suffer. The shape of the symbol is aligned based on principal components to make the recognition invariant to rotation and reflection. Then, we present the Blurred Shape Model descriptor (BSM), where new features encode the probability of appearance of each pixel that outlines the symbols shape. Moreover, we include the new descriptor in a system to deal with multi-class symbol categorization problems. Adaboost is used to train the binary classifiers, learning the BSM features that better split symbol classes. Then, the binary problems are embedded in an Error-Correcting Output Codes framework (ECOC) to deal with the multi-class case. The methodology is evaluated on different synthetic and real data sets. State-of-the-art descriptors and classifiers are compared, showing the robustness and better performance of the present scheme to classify symbols with high variability of appearance.