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Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; B. Cardenas; G. Fonseka; E. Anton; Alvaro Pascual; Richard Frodsham; Zaida Sarrate |
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Time to match; when do homologous chromosomes become closer? |
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2022 |
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Chromosoma |
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CHRO |
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In most eukaryotes, pairing of homologous chromosomes is an essential feature of meiosis that ensures homologous recombination and segregation. However, when the pairing process begins, it is still under investigation. Contrasting data exists in Mus musculus, since both leptotene DSB-dependent and preleptotene DSB-independent mechanisms have been described. To unravel this contention, we examined homologous pairing in pre-meiotic and meiotic Mus musculus cells using a threedimensional fuorescence in situ hybridization-based protocol, which enables the analysis of the entire karyotype using DNA painting probes. Our data establishes in an unambiguously manner that 73.83% of homologous chromosomes are already paired at premeiotic stages (spermatogonia-early preleptotene spermatocytes). The percentage of paired homologous chromosomes increases to 84.60% at mid-preleptotene-zygotene stage, reaching 100% at pachytene stage. Importantly, our results demonstrate a high percentage of homologous pairing observed before the onset of meiosis; this pairing does not occur randomly, as the percentage was higher than that observed in somatic cells (19.47%) and between nonhomologous chromosomes (41.1%). Finally, we have also observed that premeiotic homologous pairing is asynchronous and independent of the chromosome size, GC content, or presence of NOR regions. |
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August, 2022 |
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IAM; 601.139; 600.145; 600.096 |
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Admin @ si @ SBG2022 |
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3719 |
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Carles Sanchez; Jorge Bernal; F. Javier Sanchez; Antoni Rosell; Marta Diez-Ferrer; Debora Gil |
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Towards On-line Quantification of Tracheal Stenosis from Videobronchoscopy |
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2015 |
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International Journal of Computer Assisted Radiology and Surgery |
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IJCAR |
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10 |
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6 |
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935-945 |
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IAM; MV; 600.075 |
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Admin @ si @ SBS2015a |
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2611 |
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Marta Diez-Ferrer; Arturo Morales; Rosa Lopez Lisbona; Noelia Cubero; Cristian Tebe; Susana Padrones; Samantha Aso; Jordi Dorca; Debora Gil; Antoni Rosell |
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Ultrathin Bronchoscopy with and without Virtual Bronchoscopic Navigation: Influence of Segmentation on Diagnostic Yield |
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2019 |
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Respiration |
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RES |
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97 |
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3 |
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252-258 |
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Lung cancer; Peripheral lung lesion; Diagnosis; Bronchoscopy; Ultrathin bronchoscopy; Virtual bronchoscopic navigation |
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Background: Bronchoscopy is a safe technique for diagnosing peripheral pulmonary lesions (PPLs), and virtual bronchoscopic navigation (VBN) helps guide the bronchoscope to PPLs. Objectives: We aimed to compare the diagnostic yield of VBN-guided and unguided ultrathin bronchoscopy (UTB) and explore clinical and technical factors associated with better results. We developed a diagnostic algorithm for deciding whether to use VBN to reach PPLs or choose an alternative diagnostic approach. Methods: We compared diagnostic yield between VBN-UTB (prospective cases) and unguided UTB (historical controls) and analyzed the VBN-UTB subgroup to identify clinical and technical variables that could predict the success of VBN-UTB. Results: Fifty-five cases and 110 controls were included. The overall diagnostic yield did not differ between the VBN-guided and unguided arms (47 and 40%, respectively; p = 0.354). Although the yield was slightly higher for PPLs ≤20 mm in the VBN-UTB arm, the difference was not significant (p = 0.069). No other clinical characteristics were associated with a higher yield in a subgroup analysis, but an 85% diagnostic yield was observed when segmentation was optimal and the PPL was endobronchial (vs. 30% when segmentation was suboptimal and 20% when segmentation was optimal but the PPL was extrabronchial). Conclusions: VBN-guided UTB is not superior to unguided UTB. A greater impact of VBN-guided over unguided UTB is highly dependent on both segmentation quality and an endobronchial location of the PPL. Segmentation quality should be considered before starting a procedure, when an alternative technique that may improve yield can be chosen, saving time and resources. |
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IAM; 600.145; 600.139 |
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Admin @ si @ DML2019 |
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3134 |
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Oriol Rodriguez-Leon; Josefina Mauri;Eduard Fernandez-Nofrerias; Antonio Tovar; Vicente del Valle; Aura Hernandez-Sabate; Debora Gil; Petia Radeva |
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Utilización de la Estructura de los Campos Vectoriales para la Detección de la Adventicia en Imágenes de Ecografía Intracoronaria |
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2004 |
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Revista Internacional de Enfermedades Cardiovasculares Revista Española de Cardiología |
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57 |
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2 |
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100 |
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IAM @ iam @ RMF2004 |
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1642 |
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Oriol Rodriguez-Leon; Josefina Mauri;Eduard Fernandez-Nofrerias; Antonio Tovar; Vicente del Valle; Aura Hernandez-Sabate; Debora Gil; Petia Radeva |
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Utilizacion de la estructura de los campos vectoriales para la deteccion de la Adventicia en imagenes de Ecografia Intracoronaria |
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2004 |
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Revista Española de Cardiología |
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REC |
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57 |
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2 |
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100 |
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BCNPCL @ bcnpcl @ RMF2004 |
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