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Esmitt Ramirez, Carles Sanchez, Agnes Borras, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2018). BronchoX: bronchoscopy exploration software for biopsy intervention planning. HTL - Healthcare Technology Letters, 177–182.
Abstract: Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.
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Mireia Sole, Joan Blanco, Debora Gil, Oliver Valero, Alvaro Pascual, B. Cardenas, et al. (2021). Chromosomal positioning in spermatogenic cells is influenced by chromosomal factors associated with gene activity, bouquet formation, and meiotic sex-chromosome inactivation. Chromosoma, 130, 163–175.
Abstract: Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation.
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Ernest Valveny, & Enric Marti. (2000). Deformable Template Matching within a Bayesian Framework for Hand-Written Graphic Symbol Recognition. Graphics Recognition Recent Advances, 1941, 193–208.
Abstract: We describe a method for hand-drawn symbol recognition based on deformable template matching able to handle uncertainty and imprecision inherent to hand-drawing. Symbols are represented as a set of straight lines and their deformations as geometric transformations of these lines. Matching, however, is done over the original binary image to avoid loss of information during line detection. It is defined as an energy minimization problem, using a Bayesian framework which allows to combine fidelity to ideal shape of the symbol and flexibility to modify the symbol in order to get the best fit to the binary input image. Prior to matching, we find the best global transformation of the symbol to start the recognition process, based on the distance between symbol lines and image lines. We have applied this method to the recognition of dimensions and symbols in architectural floor plans and we show its flexibility to recognize distorted symbols.
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Jose Elias Yauri, M. Lagos, H. Vega-Huerta, P. de-la-Cruz, G.L.E Maquen-Niño, & E. Condor-Tinoco. (2023). Detection of Epileptic Seizures Based-on Channel Fusion and Transformer Network in EEG Recordings. IJACSA - International Journal of Advanced Computer Science and Applications, 14(5), 1067–1074.
Abstract: According to the World Health Organization, epilepsy affects more than 50 million people in the world, and specifically, 80% of them live in developing countries. Therefore, epilepsy has become among the major public issue for many governments and deserves to be engaged. Epilepsy is characterized by uncontrollable seizures in the subject due to a sudden abnormal functionality of the brain. Recurrence of epilepsy attacks change people’s lives and interferes with their daily activities. Although epilepsy has no cure, it could be mitigated with an appropriated diagnosis and medication. Usually, epilepsy diagnosis is based on the analysis of an electroencephalogram (EEG) of the patient. However, the process of searching for seizure patterns in a multichannel EEG recording is a visual demanding and time consuming task, even for experienced neurologists. Despite the recent progress in automatic recognition of epilepsy, the multichannel nature of EEG recordings still challenges current methods. In this work, a new method to detect epilepsy in multichannel EEG recordings is proposed. First, the method uses convolutions to perform channel fusion, and next, a self-attention network extracts temporal features to classify between interictal and ictal epilepsy states. The method was validated in the public CHB-MIT dataset using the k-fold cross-validation and achieved 99.74% of specificity and 99.15% of sensitivity, surpassing current approaches.
Keywords: Epilepsy; epilepsy detection; EEG; EEG channel fusion; convolutional neural network; self-attention
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Debora Gil, Aura Hernandez-Sabate, Julien Enconniere, Saryani Asmayawati, Pau Folch, Juan Borrego-Carazo, et al. (2022). E-Pilots: A System to Predict Hard Landing During the Approach Phase of Commercial Flights. ACCESS - IEEE Access, 10, 7489–7503.
Abstract: More than half of all commercial aircraft operation accidents could have been prevented by executing a go-around. Making timely decision to execute a go-around manoeuvre can potentially reduce overall aviation industry accident rate. In this paper, we describe a cockpit-deployable machine learning system to support flight crew go-around decision-making based on the prediction of a hard landing event.
This work presents a hybrid approach for hard landing prediction that uses features modelling temporal dependencies of aircraft variables as inputs to a neural network. Based on a large dataset of 58177 commercial flights, the results show that our approach has 85% of average sensitivity with 74% of average specificity at the go-around point. It follows that our approach is a cockpit-deployable recommendation system that outperforms existing approaches.
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