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Misael Rosales; Petia Radeva; Oriol Rodriguez-Leor; Debora Gil |
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Title |
Modelling of image-catheter motion for 3-D IVUS |
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2009 |
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Medical image analysis |
Abbreviated Journal |
MIA |
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13 |
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1 |
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91-104 |
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Intravascular ultrasound (IVUS); Motion estimation; Motion decomposition; Fourier |
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Abstract |
Three-dimensional intravascular ultrasound (IVUS) allows to visualize and obtain volumetric measurements of coronary lesions through an exploration of the cross sections and longitudinal views of arteries. However, the visualization and subsequent morpho-geometric measurements in IVUS longitudinal cuts are subject to distortion caused by periodic image/vessel motion around the IVUS catheter. Usually, to overcome the image motion artifact ECG-gating and image-gated approaches are proposed, leading to slowing the pullback acquisition or disregarding part of IVUS data. In this paper, we argue that the image motion is due to 3-D vessel geometry as well as cardiac dynamics, and propose a dynamic model based on the tracking of an elliptical vessel approximation to recover the rigid transformation and align IVUS images without loosing any IVUS data. We report an extensive validation with synthetic simulated data and in vivo IVUS sequences of 30 patients achieving an average reduction of the image artifact of 97% in synthetic data and 79% in real-data. Our study shows that IVUS alignment improves longitudinal analysis of the IVUS data and is a necessary step towards accurate reconstruction and volumetric measurements of 3-D IVUS. |
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IAM @ iam @ RRR2009 |
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1646 |
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Francesco Ciompi; Oriol Pujol; Carlo Gatta; Marina Alberti; Simone Balocco; Xavier Carrillo; J. Mauri; Petia Radeva |
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Title |
HoliMab: A Holistic Approach for Media-Adventitia Border Detection in Intravascular Ultrasound |
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Journal Article |
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2012 |
Publication |
Medical Image Analysis |
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MIA |
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16 |
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6 |
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1085-1100 |
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Media–Adventitia border detection; Intravascular ultrasound; Multi-Scale Stacked Sequential Learning; Error-correcting output codes; Holistic segmentation |
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We present a fully automatic methodology for the detection of the Media-Adventitia border (MAb) in human coronary artery in Intravascular Ultrasound (IVUS) images. A robust border detection is achieved by means of a holistic interpretation of the detection problem where the target object, i.e. the media layer, is considered as part of the whole vessel in the image and all the relationships between tissues are learnt. A fairly general framework exploiting multi-class tissue characterization as well as contextual information on the morphology and the appearance of the tissues is presented. The methodology is (i) validated through an exhaustive comparison with both Inter-observer variability on two challenging databases and (ii) compared with state-of-the-art methods for the detection of the MAb in IVUS. The obtained averaged values for the mean radial distance and the percentage of area difference are 0.211 mm and 10.1%, respectively. The applicability of the proposed methodology to clinical practice is also discussed. |
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MILAB;HuPBA |
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Admin @ si @ CPG2012 |
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1995 |
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Xose M. Pardo; Petia Radeva; D. Cabello |
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Discriminant Snakes for 3D Reconstruction of Anatomical Organs |
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2003 |
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Medical Image Analysis, 7(3): 293–310 (IF: 4.442) |
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BCNPCL @ bcnpcl @ PPC2003 |
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398 |
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Simone Balocco; O. Camara; E. Vivas; T. Sola; L. Guimaraens; H. A. van Andel; C. B. Majoie; J. M. Pozo; B. H. Bijnens; Alejandro F. Frangi |
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Title |
Feasibility of Estimating Regional Mechanical Properties of Cerebral Aneurysms In Vivo |
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2010 |
Publication |
Medical Physics |
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MEDPHYS |
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37 |
Issue |
4 |
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1689–1706 |
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PURPOSE:
In this article, the authors studied the feasibility of estimating regional mechanical properties in cerebral aneurysms, integrating information extracted from imaging and physiological data with generic computational models of the arterial wall behavior.
METHODS:
A data assimilation framework was developed to incorporate patient-specific geometries into a given biomechanical model, whereas wall motion estimates were obtained from applying registration techniques to a pair of simulated MR images and guided the mechanical parameter estimation. A simple incompressible linear and isotropic Hookean model coupled with computational fluid-dynamics was employed as a first approximation for computational purposes. Additionally, an automatic clustering technique was developed to reduce the number of parameters to assimilate at the optimization stage and it considerably accelerated the convergence of the simulations. Several in silico experiments were designed to assess the influence of aneurysm geometrical characteristics and the accuracy of wall motion estimates on the mechanical property estimates. Hence, the proposed methodology was applied to six real cerebral aneurysms and tested against a varying number of regions with different elasticity, different mesh discretization, imaging resolution, and registration configurations.
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Several in silico experiments were conducted to investigate the feasibility of the proposed workflow, results found suggesting that the estimation of the mechanical properties was mainly influenced by the image spatial resolution and the chosen registration configuration. According to the in silico experiments, the minimal spatial resolution needed to extract wall pulsation measurements with enough accuracy to guide the proposed data assimilation framework was of 0.1 mm.
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Current routine imaging modalities do not have such a high spatial resolution and therefore the proposed data assimilation framework cannot currently be used on in vivo data to reliably estimate regional properties in cerebral aneurysms. Besides, it was observed that the incorporation of fluid-structure interaction in a biomechanical model with linear and isotropic material properties did not have a substantial influence in the final results. |
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MILAB |
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BCNPCL @ bcnpcl @ BCV2010 |
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1313 |
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Simone Balocco; Carlo Gatta; Marina Alberti; Xavier Carrillo; Juan Rigla; Petia Radeva |
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Title |
Relation between plaque type, plaque thickness, blood shear stress and plaque stress in coronary arteries assessed by X-ray Angiography and Intravascular Ultrasound |
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Journal Article |
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Year |
2012 |
Publication |
Medical Physics |
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MEDPHYS |
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39 |
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12 |
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7430-7445 |
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PMID 23231293
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Atheromatic plaque progression is affected, among others phenomena, by biomechanical, biochemical, and physiological factors. In this paper, the authors introduce a novel framework able to provide both morphological (vessel radius, plaque thickness, and type) and biomechanical (wall shear stress and Von Mises stress) indices of coronary arteries.
METHODS:
First, the approach reconstructs the three-dimensional morphology of the vessel from intravascular ultrasound (IVUS) and Angiographic sequences, requiring minimal user interaction. Then, a computational pipeline allows to automatically assess fluid-dynamic and mechanical indices. Ten coronary arteries are analyzed illustrating the capabilities of the tool and confirming previous technical and clinical observations.
RESULTS:
The relations between the arterial indices obtained by IVUS measurement and simulations have been quantitatively analyzed along the whole surface of the artery, extending the analysis of the coronary arteries shown in previous state of the art studies. Additionally, for the first time in the literature, the framework allows the computation of the membrane stresses using a simplified mechanical model of the arterial wall.
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Circumferentially (within a given frame), statistical analysis shows an inverse relation between the wall shear stress and the plaque thickness. At the global level (comparing a frame within the entire vessel), it is observed that heavy plaque accumulations are in general calcified and are located in the areas of the vessel having high wall shear stress. Finally, in their experiments the inverse proportionality between fluid and structural stresses is observed. |
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MILAB |
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Admin @ si @BGA2012 |
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2170 |
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