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Simone Balocco; O. Camara; E. Vivas; T. Sola; L. Guimaraens; H. A. van Andel; C. B. Majoie; J. M. Pozo; B. H. Bijnens; Alejandro F. Frangi |
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Title |
Feasibility of Estimating Regional Mechanical Properties of Cerebral Aneurysms In Vivo |
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Journal Article |
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2010 |
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Medical Physics |
Abbreviated Journal |
MEDPHYS |
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37 |
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4 |
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1689–1706 |
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Abstract |
PURPOSE:
In this article, the authors studied the feasibility of estimating regional mechanical properties in cerebral aneurysms, integrating information extracted from imaging and physiological data with generic computational models of the arterial wall behavior.
METHODS:
A data assimilation framework was developed to incorporate patient-specific geometries into a given biomechanical model, whereas wall motion estimates were obtained from applying registration techniques to a pair of simulated MR images and guided the mechanical parameter estimation. A simple incompressible linear and isotropic Hookean model coupled with computational fluid-dynamics was employed as a first approximation for computational purposes. Additionally, an automatic clustering technique was developed to reduce the number of parameters to assimilate at the optimization stage and it considerably accelerated the convergence of the simulations. Several in silico experiments were designed to assess the influence of aneurysm geometrical characteristics and the accuracy of wall motion estimates on the mechanical property estimates. Hence, the proposed methodology was applied to six real cerebral aneurysms and tested against a varying number of regions with different elasticity, different mesh discretization, imaging resolution, and registration configurations.
RESULTS:
Several in silico experiments were conducted to investigate the feasibility of the proposed workflow, results found suggesting that the estimation of the mechanical properties was mainly influenced by the image spatial resolution and the chosen registration configuration. According to the in silico experiments, the minimal spatial resolution needed to extract wall pulsation measurements with enough accuracy to guide the proposed data assimilation framework was of 0.1 mm.
CONCLUSIONS:
Current routine imaging modalities do not have such a high spatial resolution and therefore the proposed data assimilation framework cannot currently be used on in vivo data to reliably estimate regional properties in cerebral aneurysms. Besides, it was observed that the incorporation of fluid-structure interaction in a biomechanical model with linear and isotropic material properties did not have a substantial influence in the final results. |
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BCNPCL @ bcnpcl @ BCV2010 |
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1313 |
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Neus Salvatella; E Fernandez-Nofrerias; Francesco Ciompi; Oriol Rodriguez-Leor; H. Tizon; Xavier Carrillo; J. Mauri; Petia Radeva |
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Radial Artery Volume Changes After Administration Of Two Different Intra-arterial Drug Regimens. Assessment by Intravascular Ultrasound |
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2010 |
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Journal of the American College of Cardiology |
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JACC |
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56 |
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13s1 |
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B119 |
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BCNPCL @ bcnpcl @ SFC2010b |
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1364 |
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Marina Alberti; Simone Balocco; Xavier Carrillo; J. Mauri; Petia Radeva |
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Title |
Automatic non-rigid temporal alignment of IVUS sequences: method and quantitative validation |
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Journal Article |
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2013 |
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Ultrasound in Medicine and Biology |
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UMB |
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39 |
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9 |
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1698-712 |
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Intravascular ultrasound; Dynamic time warping; Non-rigid alignment; Sequence matching; Partial overlapping strategy |
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Clinical studies on atherosclerosis regression/progression performed by intravascular ultrasound analysis would benefit from accurate alignment of sequences of the same patient before and after clinical interventions and at follow-up. In this article, a methodology for automatic alignment of intravascular ultrasound sequences based on the dynamic time warping technique is proposed. The non-rigid alignment is adapted to the specific task by applying it to multidimensional signals describing the morphologic content of the vessel. Moreover, dynamic time warping is embedded into a framework comprising a strategy to address partial overlapping between acquisitions and a term that regularizes non-physiologic temporal compression/expansion of the sequences. Extensive validation is performed on both synthetic and in vivo data. The proposed method reaches alignment errors of approximately 0.43 mm for pairs of sequences acquired during the same intervention phase and 0.77 mm for pairs of sequences acquired at successive intervention stages. |
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Admin @ si @ ABC2013 |
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2313 |
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Simone Balocco; Carlo Gatta; Marina Alberti; Xavier Carrillo; Juan Rigla; Petia Radeva |
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Relation between plaque type, plaque thickness, blood shear stress and plaque stress in coronary arteries assessed by X-ray Angiography and Intravascular Ultrasound |
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2012 |
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Medical Physics |
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MEDPHYS |
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39 |
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12 |
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7430-7445 |
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PMID 23231293
PURPOSE:
Atheromatic plaque progression is affected, among others phenomena, by biomechanical, biochemical, and physiological factors. In this paper, the authors introduce a novel framework able to provide both morphological (vessel radius, plaque thickness, and type) and biomechanical (wall shear stress and Von Mises stress) indices of coronary arteries.
METHODS:
First, the approach reconstructs the three-dimensional morphology of the vessel from intravascular ultrasound (IVUS) and Angiographic sequences, requiring minimal user interaction. Then, a computational pipeline allows to automatically assess fluid-dynamic and mechanical indices. Ten coronary arteries are analyzed illustrating the capabilities of the tool and confirming previous technical and clinical observations.
RESULTS:
The relations between the arterial indices obtained by IVUS measurement and simulations have been quantitatively analyzed along the whole surface of the artery, extending the analysis of the coronary arteries shown in previous state of the art studies. Additionally, for the first time in the literature, the framework allows the computation of the membrane stresses using a simplified mechanical model of the arterial wall.
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Circumferentially (within a given frame), statistical analysis shows an inverse relation between the wall shear stress and the plaque thickness. At the global level (comparing a frame within the entire vessel), it is observed that heavy plaque accumulations are in general calcified and are located in the areas of the vessel having high wall shear stress. Finally, in their experiments the inverse proportionality between fluid and structural stresses is observed. |
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Admin @ si @BGA2012 |
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2170 |
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G. Zahnd; Simone Balocco; A. Serusclat; P. Moulin; M. Orkisz; D. Vray |
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Progressive attenuation of the longitudinal kinetics in the common carotid artery: preliminary in vivo assessment Ultrasound in Medicine and Biology |
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2015 |
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Ultrasound in Medicine and Biology |
Abbreviated Journal |
UMB |
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41 |
Issue |
1 |
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339-345 |
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Arterial stiffness; Atherosclerosis; Common carotid artery; Longitudinal kinetics; Motion tracking; Ultrasound imaging |
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Longitudinal kinetics (LOKI) of the arterial wall consists of the shearing motion of the intima-media complex over the adventitia layer in the direction parallel to the blood flow during the cardiac cycle. The aim of this study was to investigate the local variability of LOKI amplitude along the length of the vessel. By use of a previously validated motion-estimation framework, 35 in vivo longitudinal B-mode ultrasound cine loops of healthy common carotid arteries were analyzed. Results indicated that LOKI amplitude is progressively attenuated along the length of the artery, as it is larger in regions located on the proximal side of the image (i.e., toward the heart) and smaller in regions located on the distal side of the image (i.e., toward the head), with an average attenuation coefficient of -2.5 ± 2.0%/mm. Reported for the first time in this study, this phenomenon is likely to be of great importance in improving understanding of atherosclerosis mechanisms, and has the potential to be a novel index of arterial stiffness. |
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Admin @ si @ ZBS2014 |
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2556 |
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