| |
Records |
Links |
|
Author |
Ferran Poveda; Enric Marti; Debora Gil; Francesc Carreras; Manel Ballester |
|
| |
Title |
Helical Structure of Ventricular Anatomy by Diffusion Tensor Cardiac MR Tractography |
Type |
Journal Article |
| |
Year |
2012 |
Publication |
Journal of American College of Cardiology |
Abbreviated Journal |
JACC |
|
| |
Volume |
5 |
Issue |
7 |
Pages |
754-755 |
|
| |
Keywords  |
|
|
| |
Abstract |
It is widely accepted that myocardial fiber architecture plays a critical role in myocardial contractility and relaxation (1). However, there is a lack of consensus about the distribution of the myocardial fibers and their spatial arrangement in the left and right ventricles. An understanding of the cardiac architecture should benefit the ventricular functional assessment, left ventricular reconstructive surgery planning, or resynchronization therapy in heart failure. Researchers have proposed several conceptual models to describe the architecture of the heart, ranging from gross dissection to histological presentation. The cardiac mesh model (2) proposes that the myocytes are arranged longitudinally and radially change their angulation along the myocardial depth. By contrast, the helical ventricular myocardial model states that the ventricular myocardium is a continuous anatomical helical layout of myocardial fibers (1 |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1936-878X |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM |
Approved |
no |
|
| |
Call Number |
IAM @ iam @ PMG2012 |
Serial |
1985 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
David Roche; Debora Gil; Jesus Giraldo |
|
| |
Title |
Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Drug Discovery Today |
Abbreviated Journal |
DDT |
|
| |
Volume |
18 |
Issue |
7-8 |
Pages |
365-371 |
|
| |
Keywords |
|
|
| |
Abstract |
The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Elsevier |
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM; 600.057; 600.054 |
Approved |
no |
|
| |
Call Number |
IAM @ iam @ RGG2013a |
Serial |
2190 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
David Roche; Debora Gil; Jesus Giraldo |
|
| |
Title |
Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
British Journal of Pharmacology |
Abbreviated Journal |
BJP |
|
| |
Volume |
169 |
Issue |
6 |
Pages |
1189-202 |
|
| |
Keywords |
|
|
| |
Abstract |
Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM; 600.044; 605.203 |
Approved |
no |
|
| |
Call Number |
IAM @ iam @ RGG2013b |
Serial |
2195 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Enric Marti; J.Roncaries; Debora Gil; Aura Hernandez-Sabate; Antoni Gurgui; Ferran Poveda |
|
| |
Title |
PBL On Line: A proposal for the organization, part-time monitoring and assessment of PBL group activities |
Type |
Journal |
| |
Year |
2015 |
Publication |
Journal of Technology and Science Education |
Abbreviated Journal |
JOTSE |
|
| |
Volume |
5 |
Issue |
2 |
Pages |
87-96 |
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM; ADAS; 600.076; 600.075 |
Approved |
no |
|
| |
Call Number |
Admin @ si @ MRG2015 |
Serial |
2608 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; J.Roncaries; Debora Gil |
|
| |
Title |
Automatic evaluation of practices in Moodle for Self Learning in Engineering |
Type |
Journal |
| |
Year |
2015 |
Publication |
Journal of Technology and Science Education |
Abbreviated Journal |
JOTSE |
|
| |
Volume |
5 |
Issue |
2 |
Pages |
97-106 |
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM; DAG; 600.075; 600.077 |
Approved |
no |
|
| |
Call Number |
Admin @ si @ SRM2015 |
Serial |
2610 |
|
| Permanent link to this record |
