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Frederic Sampedro, Anna Domenech, Sergio Escalera, & Ignasi Carrio. (2017). Computing quantitative indicators of structural renal damage in pediatric DMSA scans. REMNIM - Revista Española de Medicina Nuclear e Imagen Molecular, 36(2), 72–77.
Abstract: OBJECTIVES:
The proposal and implementation of a computational framework for the quantification of structural renal damage from 99mTc-dimercaptosuccinic acid (DMSA) scans. The aim of this work is to propose, implement, and validate a computational framework for the quantification of structural renal damage from DMSA scans and in an observer-independent manner.
MATERIALS AND METHODS:
From a set of 16 pediatric DMSA-positive scans and 16 matched controls and using both expert-guided and automatic approaches, a set of image-derived quantitative indicators was computed based on the relative size, intensity and histogram distribution of the lesion. A correlation analysis was conducted in order to investigate the association of these indicators with other clinical data of interest in this scenario, including C-reactive protein (CRP), white cell count, vesicoureteral reflux, fever, relative perfusion, and the presence of renal sequelae in a 6-month follow-up DMSA scan.
RESULTS:
A fully automatic lesion detection and segmentation system was able to successfully classify DMSA-positive from negative scans (AUC=0.92, sensitivity=81% and specificity=94%). The image-computed relative size of the lesion correlated with the presence of fever and CRP levels (p<0.05), and a measurement derived from the distribution histogram of the lesion obtained significant performance results in the detection of permanent renal damage (AUC=0.86, sensitivity=100% and specificity=75%).
CONCLUSIONS:
The proposal and implementation of a computational framework for the quantification of structural renal damage from DMSA scans showed a promising potential to complement visual diagnosis and non-imaging indicators.
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Simone Balocco, Francesco Ciompi, Juan Rigla, Xavier Carrillo, J. Mauri, & Petia Radeva. (2019). Assessment of intracoronary stent location and extension in intravascular ultrasound sequences. MEDPHYS - Medical Physics, 46(2), 484–493.
Abstract: PURPOSE:
An intraluminal coronary stent is a metal scaffold deployed in a stenotic artery during percutaneous coronary intervention (PCI). In order to have an effective deployment, a stent should be optimally placed with regard to anatomical structures such as bifurcations and stenoses. Intravascular ultrasound (IVUS) is a catheter-based imaging technique generally used for PCI guiding and assessing the correct placement of the stent. A novel approach that automatically detects the boundaries and the position of the stent along the IVUS pullback is presented. Such a technique aims at optimizing the stent deployment.
METHODS:
The method requires the identification of the stable frames of the sequence and the reliable detection of stent struts. Using these data, a measure of likelihood for a frame to contain a stent is computed. Then, a robust binary representation of the presence of the stent in the pullback is obtained applying an iterative and multiscale quantization of the signal to symbols using the Symbolic Aggregate approXimation algorithm.
RESULTS:
The technique was extensively validated on a set of 103 IVUS of sequences of in vivo coronary arteries containing metallic and bioabsorbable stents acquired through an international multicentric collaboration across five clinical centers. The method was able to detect the stent position with an overall F-measure of 86.4%, a Jaccard index score of 75% and a mean distance of 2.5 mm from manually annotated stent boundaries, and in bioabsorbable stents with an overall F-measure of 88.6%, a Jaccard score of 77.7 and a mean distance of 1.5 mm from manually annotated stent boundaries. Additionally, a map indicating the distance between the lumen and the stent along the pullback is created in order to show the angular sectors of the sequence in which the malapposition is present.
CONCLUSIONS:
Results obtained comparing the automatic results vs the manual annotation of two observers shows that the method approaches the interobserver variability. Similar performances are obtained on both metallic and bioabsorbable stents, showing the flexibility and robustness of the method.
Keywords: IVUS; malapposition; stent; ultrasound
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Oriol Pujol, & Petia Radeva. (2004). Texture Segmentation by Statistical Deformable Models. IJIG - International Journal of Image and Graphics, 433–452.
Abstract: Deformable models have received much popularity due to their ability to include high-level knowledge on the application domain into low-level image processing. Still, most proposed active contour models do not sufficiently profit from the application information and they are too generalized, leading to non-optimal final results of segmentation, tracking or 3D reconstruction processes. In this paper we propose a new deformable model defined in a statistical framework to segment objects of natural scenes. We perform a supervised learning of local appearance of the textured objects and construct a feature space using a set of co-occurrence matrix measures. Linear Discriminant Analysis allows us to obtain an optimal reduced feature space where a mixture model is applied to construct a likelihood map. Instead of using a heuristic potential field, our active model is deformed on a regularized version of the likelihood map in order to segment objects characterized by the same texture pattern. Different tests on synthetic images, natural scene and medical images show the advantages of our statistic deformable model.
Keywords: Texture segmentation, parametric active contours, statistic snakes
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Jaume Amores, N. Sebe, & Petia Radeva. (2006). Boosting the distance estimation: Application to the K-Nearest Neighbor Classifier. PRL - Pattern Recognition Letters, 27(3), 201–209.
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Sergio Escalera, Oriol Pujol, & Petia Radeva. (2009). Separability of Ternary Codes for Sparse Designs of Error-Correcting Output Codes. PRL - Pattern Recognition Letters, 30(3), 285–297.
Abstract: Error Correcting Output Codes (ECOC) represent a successful framework to deal with multi-class categorization problems based on combining binary classifiers. In this paper, we present a new formulation of the ternary ECOC distance and the error-correcting capabilities in the ternary ECOC framework. Based on the new measure, we stress on how to design coding matrices preventing codification ambiguity and propose a new Sparse Random coding matrix with ternary distance maximization. The results on the UCI Repository and in a real speed traffic categorization problem show that when the coding design satisfies the new ternary measures, significant performance improvement is obtained independently of the decoding strategy applied.
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