Abstract: The amount of multimedia data collected in museum databases is growing fast, while the capacity of museums to display information to visitors is acutely limited by physical space. Museums must seek the perfect balance of information given on individual pieces in order to provide sufficient information to aid visitor understanding while maintaining sparse usage of the walls and guaranteeing high appreciation of the exhibit. Moreover, museums often target the interests of average visitors instead of the entire spectrum of different interests each individual visitor might have. Finally, visiting a museum should not be an experience contained in the physical space of the museum but a door opened onto a broader context of related artworks, authors, artistic trends, etc. In this paper we describe the MNEMOSYNE system that attempts to address these issues through a new multimedia museum experience. Based on passive observation, the system builds a profile of the artworks of interest for each visitor. These profiles of interest are then used to drive an interactive table that personalizes multimedia content delivery. The natural user interface on the interactive table uses the visitor’s profile, an ontology of museum content and a recommendation system to personalize exploration of multimedia content. At the end of their visit, the visitor can take home a personalized summary of their visit on a custom mobile application. In this article we describe in detail each component of our approach as well as the first field trials of our prototype system built and deployed at our permanent exhibition space at LeMurate (http://www.lemurate.comune.fi.it/lemurate/) in Florence together with the first results of the evaluation process during the official installation in the National Museum of Bargello (http://www.uffizi.firenze.it/musei/?m=bargello).