Abstract: Characterization of carotid plaque composition, more specifically the amount of lipid core, fibrous tissue, and calcified tissue, is an important task for the identification of plaques that are prone to rupture, and thus for early risk estimation of cardiovascular and cerebrovascular events. Due to its low costs and wide availability, carotid ultrasound has the potential to become the modality of choice for plaque characterization in clinical practice. However, its significant image noise, coupled with the small size of the plaques and their complex appearance, makes it difficult for automated techniques to discriminate between the different plaque constituents. In this paper, we propose to address this challenging problem by exploiting the unique capabilities of the emerging deep learning framework. More specifically, and unlike existing works which require a priori definition of specific imaging features or thresholding values, we propose to build a convolutional neural network (CNN) that will automatically extract from the images the information that is optimal for the identification of the different plaque constituents. We used approximately 90 000 patches extracted from a database of images and corresponding expert plaque characterizations to train and to validate the proposed CNN. The results of cross-validation experiments show a correlation of about 0.90 with the clinical assessment for the estimation of lipid core, fibrous cap, and calcified tissue areas, indicating the potential of deep learning for the challenging task of automatic characterization of plaque composition in carotid ultrasound.

Abstract: Multi-modal medical image fusion plays an important role in clinical diagnosis and works as an assistance model for clinicians. In this paper, a computed tomography-magnetic resonance (CT-MR) image fusion model is proposed using an optimized bio-inspired spiking feedforward neural network in different decomposition domains. First, source images are decomposed into base (low-frequency) and detail (high-frequency) layer components. Low-frequency subbands are fused using texture energy measures to capture the local energy, contrast, and small edges in the fused image. High-frequency coefficients are fused using firing maps obtained by pixel-activated neural model with the optimized parameters using three different optimization techniques such as differential evolution, cuckoo search, and gray wolf optimization, individually. In the optimization model, a fitness function is computed based on the edge index of resultant fused images, which helps to extract and preserve sharp edges available in the source CT and MR images. To validate the fusion performance, a detailed comparative analysis is presented among the proposed and state-of-the-art methods in terms of quantitative and qualitative measures along with computational complexity. Experimental results show that the proposed method produces a significantly better visual quality of fused images meanwhile outperforms the existing methods.