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Francesco Ciompi; Oriol Pujol; Carlo Gatta; Marina Alberti; Simone Balocco; Xavier Carrillo; J. Mauri; Petia Radeva |
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Title |
HoliMab: A Holistic Approach for Media-Adventitia Border Detection in Intravascular Ultrasound |
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Journal Article |
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2012 |
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Medical Image Analysis |
Abbreviated Journal |
MIA |
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16 |
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6 |
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1085-1100 |
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Media–Adventitia border detection; Intravascular ultrasound; Multi-Scale Stacked Sequential Learning; Error-correcting output codes; Holistic segmentation |
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Abstract |
We present a fully automatic methodology for the detection of the Media-Adventitia border (MAb) in human coronary artery in Intravascular Ultrasound (IVUS) images. A robust border detection is achieved by means of a holistic interpretation of the detection problem where the target object, i.e. the media layer, is considered as part of the whole vessel in the image and all the relationships between tissues are learnt. A fairly general framework exploiting multi-class tissue characterization as well as contextual information on the morphology and the appearance of the tissues is presented. The methodology is (i) validated through an exhaustive comparison with both Inter-observer variability on two challenging databases and (ii) compared with state-of-the-art methods for the detection of the MAb in IVUS. The obtained averaged values for the mean radial distance and the percentage of area difference are 0.211 mm and 10.1%, respectively. The applicability of the proposed methodology to clinical practice is also discussed. |
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MILAB;HuPBA |
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no |
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Admin @ si @ CPG2012 |
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1995 |
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Simone Balocco; O. Camara; E. Vivas; T. Sola; L. Guimaraens; H. A. van Andel; C. B. Majoie; J. M. Pozo; B. H. Bijnens; Alejandro F. Frangi |
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Title |
Feasibility of Estimating Regional Mechanical Properties of Cerebral Aneurysms In Vivo |
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Journal Article |
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2010 |
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Medical Physics |
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MEDPHYS |
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37 |
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4 |
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1689–1706 |
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PURPOSE:
In this article, the authors studied the feasibility of estimating regional mechanical properties in cerebral aneurysms, integrating information extracted from imaging and physiological data with generic computational models of the arterial wall behavior.
METHODS:
A data assimilation framework was developed to incorporate patient-specific geometries into a given biomechanical model, whereas wall motion estimates were obtained from applying registration techniques to a pair of simulated MR images and guided the mechanical parameter estimation. A simple incompressible linear and isotropic Hookean model coupled with computational fluid-dynamics was employed as a first approximation for computational purposes. Additionally, an automatic clustering technique was developed to reduce the number of parameters to assimilate at the optimization stage and it considerably accelerated the convergence of the simulations. Several in silico experiments were designed to assess the influence of aneurysm geometrical characteristics and the accuracy of wall motion estimates on the mechanical property estimates. Hence, the proposed methodology was applied to six real cerebral aneurysms and tested against a varying number of regions with different elasticity, different mesh discretization, imaging resolution, and registration configurations.
RESULTS:
Several in silico experiments were conducted to investigate the feasibility of the proposed workflow, results found suggesting that the estimation of the mechanical properties was mainly influenced by the image spatial resolution and the chosen registration configuration. According to the in silico experiments, the minimal spatial resolution needed to extract wall pulsation measurements with enough accuracy to guide the proposed data assimilation framework was of 0.1 mm.
CONCLUSIONS:
Current routine imaging modalities do not have such a high spatial resolution and therefore the proposed data assimilation framework cannot currently be used on in vivo data to reliably estimate regional properties in cerebral aneurysms. Besides, it was observed that the incorporation of fluid-structure interaction in a biomechanical model with linear and isotropic material properties did not have a substantial influence in the final results. |
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MILAB |
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BCNPCL @ bcnpcl @ BCV2010 |
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1313 |
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Simone Balocco; Carlo Gatta; Marina Alberti; Xavier Carrillo; Juan Rigla; Petia Radeva |
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Relation between plaque type, plaque thickness, blood shear stress and plaque stress in coronary arteries assessed by X-ray Angiography and Intravascular Ultrasound |
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Journal Article |
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2012 |
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Medical Physics |
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MEDPHYS |
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39 |
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12 |
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7430-7445 |
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PMID 23231293
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Atheromatic plaque progression is affected, among others phenomena, by biomechanical, biochemical, and physiological factors. In this paper, the authors introduce a novel framework able to provide both morphological (vessel radius, plaque thickness, and type) and biomechanical (wall shear stress and Von Mises stress) indices of coronary arteries.
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First, the approach reconstructs the three-dimensional morphology of the vessel from intravascular ultrasound (IVUS) and Angiographic sequences, requiring minimal user interaction. Then, a computational pipeline allows to automatically assess fluid-dynamic and mechanical indices. Ten coronary arteries are analyzed illustrating the capabilities of the tool and confirming previous technical and clinical observations.
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The relations between the arterial indices obtained by IVUS measurement and simulations have been quantitatively analyzed along the whole surface of the artery, extending the analysis of the coronary arteries shown in previous state of the art studies. Additionally, for the first time in the literature, the framework allows the computation of the membrane stresses using a simplified mechanical model of the arterial wall.
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Circumferentially (within a given frame), statistical analysis shows an inverse relation between the wall shear stress and the plaque thickness. At the global level (comparing a frame within the entire vessel), it is observed that heavy plaque accumulations are in general calcified and are located in the areas of the vessel having high wall shear stress. Finally, in their experiments the inverse proportionality between fluid and structural stresses is observed. |
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MILAB |
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Admin @ si @BGA2012 |
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2170 |
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Simone Balocco; Francesco Ciompi; Juan Rigla; Xavier Carrillo; J. Mauri; Petia Radeva |
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Assessment of intracoronary stent location and extension in intravascular ultrasound sequences |
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2019 |
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Medical Physics |
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MEDPHYS |
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46 |
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2 |
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484-493 |
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IVUS; malapposition; stent; ultrasound |
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PURPOSE:
An intraluminal coronary stent is a metal scaffold deployed in a stenotic artery during percutaneous coronary intervention (PCI). In order to have an effective deployment, a stent should be optimally placed with regard to anatomical structures such as bifurcations and stenoses. Intravascular ultrasound (IVUS) is a catheter-based imaging technique generally used for PCI guiding and assessing the correct placement of the stent. A novel approach that automatically detects the boundaries and the position of the stent along the IVUS pullback is presented. Such a technique aims at optimizing the stent deployment.
METHODS:
The method requires the identification of the stable frames of the sequence and the reliable detection of stent struts. Using these data, a measure of likelihood for a frame to contain a stent is computed. Then, a robust binary representation of the presence of the stent in the pullback is obtained applying an iterative and multiscale quantization of the signal to symbols using the Symbolic Aggregate approXimation algorithm.
RESULTS:
The technique was extensively validated on a set of 103 IVUS of sequences of in vivo coronary arteries containing metallic and bioabsorbable stents acquired through an international multicentric collaboration across five clinical centers. The method was able to detect the stent position with an overall F-measure of 86.4%, a Jaccard index score of 75% and a mean distance of 2.5 mm from manually annotated stent boundaries, and in bioabsorbable stents with an overall F-measure of 88.6%, a Jaccard score of 77.7 and a mean distance of 1.5 mm from manually annotated stent boundaries. Additionally, a map indicating the distance between the lumen and the stent along the pullback is created in order to show the angular sectors of the sequence in which the malapposition is present.
CONCLUSIONS:
Results obtained comparing the automatic results vs the manual annotation of two observers shows that the method approaches the interobserver variability. Similar performances are obtained on both metallic and bioabsorbable stents, showing the flexibility and robustness of the method. |
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MILAB; no proj |
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Admin @ si @ BCR2019 |
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3231 |
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Author |
Pedro Martins; Paulo Carvalho; Carlo Gatta |
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Title |
Context-aware features and robust image representations |
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Journal Article |
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2014 |
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Journal of Visual Communication and Image Representation |
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JVCIR |
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25 |
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2 |
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339-348 |
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Local image features are often used to efficiently represent image content. The limited number of types of features that a local feature extractor responds to might be insufficient to provide a robust image representation. To overcome this limitation, we propose a context-aware feature extraction formulated under an information theoretic framework. The algorithm does not respond to a specific type of features; the idea is to retrieve complementary features which are relevant within the image context. We empirically validate the method by investigating the repeatability, the completeness, and the complementarity of context-aware features on standard benchmarks. In a comparison with strictly local features, we show that our context-aware features produce more robust image representations. Furthermore, we study the complementarity between strictly local features and context-aware ones to produce an even more robust representation. |
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LAMP; 600.079;MILAB |
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Admin @ si @ MCG2014 |
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2467 |
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